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June 5, 2025 Tyler C. Diorio
Request for Proposals - Exploring expanded consciousness and endogenous DMT Sponsor: DMT Quest Aim of Funding This funding seeks to advance scientific understanding of consciousness, human potential, and the mechanisms underlying expanded awareness. Eligible research may investigate endogenous N,N-dimethyltryptamine (DMT) and its role in human consciousness, but we also welcome innovative...
Molecular Neurobiology June 4, 2025 Naser-Aldin Lashgari, Mahla Khalaji, Pouria Rana et al. 7 citations
Neurological and psychiatric disorders are considered one of the major problems of today's societies and cause many individual and social problems. Current treatments are effective, but due to their burdens, there is always an effort to introduce novel treatments. Psychedelics, a diverse group of psychoactive compounds, including LSD, psilocybin, DMT, MDMA, and ketamine, have shown potential in...
June 2, 2025 Kande Lekamalaya Senarath Dayathilake 1 citation
The mechanisms underlying consciousness and its potential continuity beyond biological death remain pivotal challenges in neuroscience. This study integrates quantum biology, cognitive psychology, and thought experiments to propose a novel framework in which consciousness persists through hypothetical particles. Using three hypothetical scenarios—brain revival, molecular disassembly/reassembly,...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie June 2025 Gianluca Lavanco, Valentina Castelli, Cesare D'Amico et al.
Mitochondria are central to cellular energy metabolism, contributing to synaptic transmission and plasticity. The mitochondrial membranes present the cannabinoid type-1 receptor (mito-CB1R), which has been functionally linked to neuronal energy supply and cognitive processing. Prenatal exposure to Δ9-tetrahydrocannabinol (pTHC) has been associated with cognitive impairments associated with...
Cureus June 1, 2025 Amy Avakian, Zachary I Merhavy 1 citation
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuroinflammation. Despite extensive research, current therapeutic options offer limited symptomatic relief without altering disease progression. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist traditionally used as an anesthetic, has garnered...
Computers in biology and medicine June 1, 2025 Swapna Sasi, Basabdatta Sen Bhattacharya, Vanteemar S Sreeraj et al.
We present a neural mass model (NMM) of the brain thalamo-cortico-thalamic (TCT) network to understand the effectiveness of non-invasive treatment with transcranial Direct Current Stimulation (tDCS) in reversing the anomalous electroencephalogram (EEG) oscillations in Schizophrenia. Our TCT NMM consists of twelve neural populations representing the thalamus and cortex modules of the visual...
Expert Opinion on Therapeutic Targets June 1, 2025 Naomi Xiao, Liyang Yin, Kayla M Teopiz et al. 5 citations
The mechanism of action of antidepressants is not fully ascertained. In addition to monoamines, disparate other effectors are also implicated in the molecular and cellular effects of chronic stress including neurogenesis, neurodifferentiation, and neuroplasticity. Evidence suggests sigma-1 receptors (S1Rs) as a putative target and possible mediator of antidepressant activity. Data from...
Asian Journal of Psychiatry June 1, 2025 Mingrui Chen, Jingyan Jin, Hongsheng Bi et al. 12 citations
N-methyl-D-aspartate receptors (NMDA receptors) play a crucial role as ionotropic glutamate receptors in regulating neuroplasticity, learning, memory, and a range of psychiatric disorders. Studies indicate that dysfunction of NMDA receptors is a key pathological mechanism in depression, where abnormal activation can result in neuronal excitotoxicity, excessive extracellular calcium ion...
Nature June 1, 2025 Ling-Xiao Shao, Clara Liao, Pasha A. Davoudian et al. 75 citations
Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses1-4. At the cellular level, psychedelics induce structural neural plasticity5,6, exemplified by the drug-evoked growth and remodelling of dendritic spines in cortical pyramidal cells7-9. A key question is how these cellular modifications map onto cell-type-specific circuits to produce the...
Journal of Cannabis Research May 31, 2025 Michael Von Gunten, Seth Hoffman, Addison Smartt et al.
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...