Drug Metabolism and Disposition
July 1, 2025
Severin Mairinger, Mihye Kwon, Martin Bauer et al.
An important safety consideration for topically administered drugs is the extent of systemic exposure they achieve. The aim of this study was to evaluate whether a topically administered microdose of the model drug diclofenac can predict the systemic availability, plasma, and tissue pharmacokinetics of a topical therapeutic dose. Eight healthy participants (6 men and 2 women) participated in a...
The Brown University Psychopharmacology Update
July 1, 2025
Microdosing of lysergic acid diethylamide (LSD) over a 6‐week period showed no significant benefits over placebo in reducing symptoms of attention‐deficit hyperactivity disorder (ADHD) in adults, a Phase 2A trial has found. Both the LSD and placebo groups experienced marked improvement, the investigators reported.
Veterinary medicine and science
July 1, 2025
Elisa Hernández-Álvarez, Lucas F Borkel, Jaime Rojas-Hernández et al.
3 citations
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The...
British Journal of Clinical Pharmacology
June 16, 2025
Wellenberg K Simon, Tanja M Gampfer, Wagmann Lea et al.
1 citation
The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB-CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human metabolites in literature. Finally, metabolites...
International Journal of Agronomy
June 10, 2025
Kinfe Tekulu, Gebresemaeti Kahsu, Weldegebriel Gebrehiwot et al.
Optimizing organic fertilizer recommendations can be cost-effective and affordable for resource-poor farmers by increasing crop yield and income. This field experiment was conducted to determine the most effective vermicompost application method for enhancing maize production in the Laelay Adiyabo district (Chiraro, Gudelo, and Hibret experimental sites) of Tigray, Ethiopia, during the 2019...
BJPsych Open
June 1, 2025
Zelda Summers, Jennie Rankine, Stuart Fisher
Aims: For patients prescribed methadone wishing to access buprenorphine ORT, the current practice is to reduce the methadone dose to 30/40 ml and cessation of methadone for 48 hrs prior to the switch. This exposes these patients to risk of psychological, physical distress or relapse into non-prescribed opiate use. Using guidance published by the Canadian Journal of Addiction we adapted this to...
Neurology
May 16, 2025
Sneha Mantri
Her earrings tremble as she tilts her head.Voice cracking, he mimes the difficulty of spooning soup up to his mouth.The MRI's pixels reflect off his glasses, obscuring the worry in his eyes.
Neuroscience & Biobehavioral Reviews
May 9, 2025
Rotem Petranker, Benjamin Tsang, Omer A. Syed
3 citations
Microdosing, the repeated use of psychedelic substances at low doses, is growing in popularity among recreational consumers. While this practice is associated with many benefits to mood, well-being and health, research in this area is in its early stages and predominantly centered on human applications. In this narrative review, we synthesize the findings from studies investigating the effects...
Cureus
May 1, 2025
Alyssa Kong, Viseth Long, Elle Wang et al.
Introduction To address the rising deaths and hospitalizations related to opioid toxicity, buprenorphine/naloxone has been provided as a frontline treatment within the emergency department (ED), allowing increased access to opioid agonist therapies (OAT). However, several barriers exist toward initiating patients on buprenorphine/naloxone within the ED, such as shortages in healthcare staff and...
Discover Agriculture
April 6, 2025
Woumou Kamkam, Adama Coulibaly, Jens B. Aune
Abstract This study aimed to determine the optimal maize NPK microdosing rate in Mali and compare labor requirements for mechanized versus manual sowing and fertilization across three locations with varying rainfall. The treatments included six microdosing rates, ranging from zero to 93 kg NPK/ha (3 g NPK/hill), and the recommended rate of 100 kg NPK/ha applied by row application. All...