This review is limited by the heterogeneity in reporting side effects and the short duration of many studies. Future studies should transparently and systematically present a description of side effects.
Existing research highlights an increase in psychedelic microdosing, particularly for therapeutic purposes and as a means for self-enhancement. However, we know little about the different routes into and out of microdosing, particularly by those who do not consume other illicit substances, and of the processes involved in the development, maintenance, and cessation of practices. Drawing upon a...
Enhanced creativity is often cited as an effect of microdosing (taking repeated low doses of a psychedelic drug). There have been recent efforts to validate the reported effects of microdosing, however creativity remains a difficult construct to quantify. The current study aimed to assess microdosing's effects on creativity using a multimodal battery of tests as part of a randomised controlled...
In June 2024, Arizona Department of Health Services (ADHS) was notified by Arizona's poison control centers (PCCs)* of adverse health outcomes occurring after ingestion of a Diamond Shruumz-brand product containing proprietary blends of mushroom extracts and adaptogens.† These products were sold as chocolate bars, gummies, and cones and could be purchased online or at local retailers...
This present study aimed at evaluating the effect of fertilizer rate and time of application on yield, and determined the availability of soil P and S to S. macrocarpon. The experiment was conducted in the derived savanna (Ogbomoso) and the rainforest (Ilesha) in southwest Nigeria. The treatments were arranged in a factorial combination and laid out in a split-plot design with four replicates....
Due to severely weathered soils and copious amounts of rainfall, the timing and rate of fertilizer application to enhance yields, nitrogen use efficiency, and recovery of fluted pumpkin (Telfairia occidentalis) have been key concerns in southwestern Nigeria. The experiment was conducted using a 2 x 2 x 5 randomized complete block split plot design (RCBSPD) with four varieties. Ilesa and...
Intravenous administration of indocyanine green (ICG) has been approved in brain surgeries for decades, yet concerns about neurotoxicity prevent its direct administration into the cerebrospinal fluid (CSF). Armed with prior animal studies demonstrating the feasibility of using ICG microdosing into the CSF, we sought to evaluate its nonclinical safety profile and obtain surrogate measures in...
Clinical trials using full doses of psychedelics have provided preliminary evidence supporting their safety and efficacy in treating a variety of physical and psychological conditions. Anecdotal reports indicate that even very small amounts of these substances may provide therapeutic benefits, though robust clinical studies are still needed. This chapter reviews the current experimental studies...
The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significant subset of psychiatric conditions, particularly major depressive and anxiety disorders. Anti-inflammatory interventions have demonstrated benefit in these conditions. Psilocin, the active ingredient of mushrooms in the...
NeuroscienceDecember 17, 2024Erin B Rousseau, Hannah D Jackson, Suman Guha et al.
Targeted intracranial delivery of molecularly-specific therapies within intricate brain structures poses a formidable challenge due to the heterogeneity of neuronal phenotypes and functions. Here we report the use of an implantable, miniaturized neural drug delivery system permitting dynamic adjustment of pharmacotherapies. Specifically, we exploit the spatial accuracy afforded by this method...