Additive manufacturing offers unprecedented opportunities for personalized medicine, but most pharmaceutical printing platforms are optimized for milligram-range doses, limiting their suitability for microdosing. This work introduces a novel liquid deposition approach using a modified technical pen integrated into a pharmaceutical printer. The gravity-driven mechanism enabled precise microscale...
Microdosing — once a niche practice whispered about in online forums and tech circles — has firmly entered the mainstream. A new RAND survey suggests that millions of U.S. adults are now taking sub‐perceptual amounts of psychedelics such as psilocybin, LSD and MDMA, often with goals that differ sharply from those associated with traditional, full‐dose use.
Fertiliser microdosing (FM) is widely promoted in sub‐Saharan Africa as a means to improve fertiliser use efficiency in cereal crops. However, combining organic amendments with FM could further increase the agronomic efficiency of the latter because of possible synergies between both practices. This study therefore evaluated whether combining FM with organic amendments enhanced fertiliser use...
The small‐scale farmers of semiarid southern Africa are experiencing chronic water and nutrient shortages due to climate change; however, very few initiatives have been put in place to optimize the production of underutilized drought‐tolerant small grains that currently give poor yields of less than 0.8 t ha −1 using conventional planting techniques. The current experiment was undertaken to...
Microdosing psychedelics has attracted growing attention from public commentators, scientists, investors and user communities across the globe. Microdosing is the use of small doses of psychedelic substances such as psilocybin mushrooms and LSD. Its proponents speak of microdosing as a use modality that improves various human abilities and life areas, including cognitive function, mood,...
While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting. A retrospective mixed-method survey was conducted with 365...
Microdosing - the practice of consuming extremely low doses of classical psychedelic substances that do not elicit overt psychedelic effects - has gained significant attention as a potential method for enhancing cognitive performance. However, findings from controlled studies remain mixed and inconclusive. This preregistered meta-analysis examined the cognitive effects of classical psychedelic...
Participation in trials investigating psychedelic-assisted MCP may offer hope for patients and their caregivers. Given the bidirectional relationship in wellbeing between cancer dyads, caregivers should be included alongside patients in such trials.
Soybean cultivation has expanded among farmers in Benin, yet yields remain below potential, mainly due to declining soil fertility and poor seed quality. This study evaluated the effects of organo-mineral microdose fertilization and rhizobium inoculation on the agronomic performance of three soybean varieties in the sub-humid zone of Northern Benin over two consecutive growing seasons. A...
Expectations can impact antidepressant treatment and psychedelic therapy, often enhancing placebo effects and influencing outcomes. However, research in this context is lacking. Our study explored the expectations of participants with major depressive disorder (MDD) before microdosing lysergic acid diethylamide (LSD) in an open-label trial. Twenty-three individuals with MDD completed a...