Clinical Toxicology
2010
Shaun D. Carstairs, F. Lee Cantrell
48 citations
Although uncommonly encountered, use of peyote and mescaline was associated with clinically significant effects requiring treatment in a substantial number of patients. Clinical effects were usually mild or moderate, and life-threatening toxicity was not reported in this case series.
Oxidative Medicine and Cellular Longevity
2009
Peter Kovacic, Ratnasamy Somanathan
34 citations
A unifying mechanism for abused drugs has been proposed previously from the standpoint of electron transfer. Mescaline can be accommodated within the theoretical framework based on redox cycling by the catechol metabolite with its quinone counterpart. Electron transfer may play a role in electrical effects involving the nervous system in the brain. This approach is in accord with structure...
Contemporary Justice Review
December 1, 2007
Peter N. Jones
31 citations
Since the passage of the Comprehensive Drug Abuse Prevention and Control Act of 1970, Native American Church (NAC) members have continually had to defend their legal right to use the sacred cactus peyote (Lophophora williamsii). This legal right was established with the passage of 21 CFR 1307.31, which exempts peyote's Schedule I status for NAC members. The exemption, however, continues to be...
ChemInform
November 6, 2007
Ricardo de L. Barreto, Laura B. L. R. Nascimbem, Carlos R. D. Correira
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Psychopharmacology
October 6, 2007
Tomáš Páleníček, Marie Balı́ková, Vĕra Bubeníková‐valešová et al.
61 citations
RationaleMescaline is a nonselective serotonin receptor agonist. It has relatively delayed onset of action and prolonged duration. Mescaline attenuates various behavioral parameters in rats; however, no information is available about its pharmacokinetics in rats and its relation to the behavioral changes produced by the drug.ObjectivesThe present study evaluates the spontaneous locomotor...
Synthetic Communications
June 1, 2007
Ricardo de L. Barreto, Laura B. L. R. Nascimbem, Carlos Roque D. Correia
8 citations
Abstract The total synthesis of the 3‐(3,4,5-trimethoxyphenyl)-pyrrolidine, a new and conformationally constrained mescaline analogue, was accomplished in a concise and efficient manner. The synthetic route encompassed only 4 steps from the starting N-Cbz-3-pyrrolidine, in 46% overall yield. The route features a highly effective Heck arylation of the non-activated olefin N-Cbz-3-pyrrolidine...
ChemInform
March 27, 2007
Dino Alberico, Mark Lautens
2 citations
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synlett
October 25, 2006
Mark Lautens, Dino Alberico
10 citations
A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot. A variety of symmetrical and unsymmetrical tricyclic heterocycles were synthesized in good yields from a Heck acceptor and an aryl iodide containing two tethered alkyl bromides. This methodology was applied to the synthesis of a tricyclic mescaline...
Journal of Medicinal Chemistry
June 21, 2006
Thomas H. Mclean, James J. Chambers, Jason C. Parrish et al.
24 citations
A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was designed using a 5-HT(2A) receptor homology model. The compound possessed 3-fold higher affinity and potency than and efficacy equal to that of mescaline at the 5-HT(2A) receptor. The new analogue substituted fully for LSD in drug discrimination studies and was 5-fold more potent than mescaline....
Revista de Neurología
2006
Francisco Javier Carod-Artal, C Vázquez-cabrera
27 citations
INTRODUCTION: The San Pedro cactus contains the alkaloid mescaline and other derivates of phenethylamine with hallucinogenic properties. This cactus was used throughout history by a number of different pre-Columbine cultures and civilisations that settled in northern Peru. In this article we review the ethno-archaeological and ethno-historical evidence of the ritual use of the San Pedro cactus...