Pharmacological Reports
August 2014
Anna Maria Górska, Karolina Noworyta-Sokołowska, Krystyna Gołembiowska
The psychostimulant 3,4-methylenedioxymethamphetamine (MDMA) with a strong addictive potential is widely used as a recreational drug. Neurotoxicity of MDMA is related with the generation of highly reactive free radicals. MDMA was given in doses of 20 and 40mg/kg ip alone or in combination with caffeine (CAF) 10mg/kg ip. Extracellular concentration of hydroxyl radical was measured using...
UTAS Research Repository
August 1, 2014
Emma Rouse
Tests of verbal learning and memory have frequently been used to examine memory performance in frequent 3,4-methylendioxymethamphetamine (ecstasy‚ÄövÑvp) consumers, and meta-analyses have identified verbal learning and memory as the cognitive domain most adversely affected by regular ecstasy use (eg. Kalechstein, et al., 2007; Zakzanis, Campbell & Jovanovski, 2007). Tests of verbal memory are...
Journal of Pharmacology and Experimental Therapeutics
August 2014
Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa et al.
Previous studies have demonstrated that methylphenidate, MDMA (3,4-methylenedioxymethamphetamine), and other psychostimulants exert stimulant-like subjective effects in humans. Furthermore, MDMA and methylphenidate substitute for the discriminative stimulus effects of psychostimulants, such as amphetamine and cocaine, in animals, which suggests that MDMA and methylphenidate may produce similar...
European Neuropsychopharmacology
August 2014
Ruud P. W. Litjens, Tibor M Brunt, Gerard-Jan Alderliefste et al.
Hallucinogen persisting perception disorder (HPPD) is a drug-induced condition associated with inaccurate visual representations. Since the underlying mechanism(s) are largely unknown, this review aims to uncover aspects underlying its etiology. Available evidence on HPPD and drug-related altered visual processing was reviewed and the majority of HPPD cases were attributed to drugs with...
Archives of Toxicology
August 2014
Daniel José Barbosa, Roman Serrat, Serena Mirra et al.
Identification of the mechanisms by which drugs of abuse cause neuronal dysfunction is essential for understanding the biological bases of their acute and long-lasting effects in the brain. Here, we performed real-time functional experiments of axonal transport of mitochondria to explore the role of in situ mitochondrial dysfunction in 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy")-related...
Journal of Psychopharmacology
July 22, 2014
Yasmin Schmid, Cédric M. Hysek, Linda D. Simmler et al.
154 citations
Social cognition is important in everyday-life social interactions. The social cognitive effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) and methylphenidate (both used for neuroenhancement and as party drugs) are largely unknown. We investigated the acute effects of MDMA (75 mg), methylphenidate (40 mg) and placebo using the Facial Emotion Recognition Task, Multifaceted Empathy...
International Journal of Drug Policy
July 15, 2014
Hanna Uosukainen, Ulrich Tacke, Adam Winstock
55 citations
BackgroundEvidence regarding MDMA (ecstasy) dependence and the most suitable criteria for its assessment are controversial. This study aimed to assess the prevalence of last year symptoms of dependence upon MDMA compared to cocaine, mephedrone and ketamine among a large global non-treatment seeking sample.MethodsA cross-sectional anonymous online survey was promoted by a UK-based dance music...
Behavioural Pharmacology
July 11, 2014
A. C. Parrott, Catharine Montgomery, Mark Wetherell et al.
34 citations
Stress develops when an organism requires additional metabolic resources to cope with demanding situations. This review will debate how recreational 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') can increase some aspects of acute and chronic stress in humans. Laboratory studies on the acute effects of MDMA on cortisol release and neurohormone levels in drug-free regular ecstasy/MDMA users...
Annals of Pharmacotherapy
July 2014
C Michael White
Review the current literature assessing the role of 3,4-methylenedioxymethamphetamine (MDMA) on posttraumatic stress disorder (PTSD). OVID MEDLINE search (1960-February 2014) using the terms MDMA, 3,4-methylenedioxymethamphetamine, Molly, and Ecstasy crossed with posttraumatic stress disorder with backwards citation tracking using references from procured articles. English language studies...
Developmental Psychobiology
July 1, 2014
Brian J. Piper, Christina S. Henderson, Jerrold S. Meyer
2 citations
AbstractIntermittent MDMA pretreatment blocked the reductions in serotonin transporter (SERT) binding induced by an MDMA binge in a prior study in adolescent male rats. The objective of this investigation was to determine if the physiological, behavioral, and neurochemical responses to MDMA are sexually dimorphic. Female Sprague–Dawley rats received MDMA (10 mg/kg × 2) or Saline on every fifth...