3 papers in the library · 74 citations · publishing 2014-2016
Clinical Toxicology May 31, 2016 Tibor M Brunt, Ruud P. W. Litjens
We concur with the observation of the authors that ibogaine does not seem to have a clear therapeutic dose margin, nor does iboga extracts or the root bark of iboga. However, what they consider to ...
Clinical Toxicology 2016 Ruud P. W. Litjens, Tibor M Brunt 74 citations
Ibogaine is a psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe Iboga. It is unlicensed but used in the treatment of drug and alcohol addiction. However, reports of ibogaine's toxicity are cause for concern. To review ibogaine's pharmacokinetics and pharmacodynamics, mechanisms of action and reported toxicity. A search of the literature available on PubMed was done,...
European Neuropsychopharmacology August 2014 Ruud P. W. Litjens, Tibor M Brunt, Gerard-Jan Alderliefste et al.
Hallucinogen persisting perception disorder (HPPD) is a drug-induced condition associated with inaccurate visual representations. Since the underlying mechanism(s) are largely unknown, this review aims to uncover aspects underlying its etiology. Available evidence on HPPD and drug-related altered visual processing was reviewed and the majority of HPPD cases were attributed to drugs with...