2 papers in the library · 74 citations · publishing 2016
Clinical Toxicology May 31, 2016 Tibor M Brunt, Ruud P. W. Litjens
We concur with the observation of the authors that ibogaine does not seem to have a clear therapeutic dose margin, nor does iboga extracts or the root bark of iboga. However, what they consider to ...
Clinical toxicology (Philadelphia, Pa.) 2016 Ruud P. W. Litjens, Tibor M Brunt 74 citations
Ibogaine is a psychoactive indole alkaloid found in the African rainforest shrub Tabernanthe Iboga. It is unlicensed but used in the treatment of drug and alcohol addiction. However, reports of ibogaine's toxicity are cause for concern. To review ibogaine's pharmacokinetics and pharmacodynamics, mechanisms of action and reported toxicity. A search of the literature available on PubMed was done,...