The effect of caffeine on MDMA-induced hydroxyl radical production in the mouse striatum.
Anna Maria Górska, Karolina Noworyta-Sokołowska, Krystyna Gołembiowska
Pharmacological Reports August 2014 DOI: 10.1016/j.pharep.2014.03.003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Freely moving mice |
| Interventions | MDMA Caffeine |
| Dose | MDMA 20 and 40 mg/kg ip; caffeine 10 mg/kg ip |
| Measures | HPLC with electrochemical detection |
| Topics | MDMA |
| Keywords | Caffeine Hydroxyl radical |
| Key findings | MDMA dose-dependently increased hydroxyl radical production in the mouse striatum, and caffeine (10 mg/kg) reversed this increase. The authors argue that caffeine may have neuroprotective properties by reducing MDMA-induced oxidative stress. |
Abstract
The psychostimulant 3,4-methylenedioxymethamphetamine (MDMA) with a strong addictive potential is widely used as a recreational drug. Neurotoxicity of MDMA is related with the generation of highly reactive free radicals. MDMA was given in doses of 20 and 40mg/kg ip alone or in combination with caffeine (CAF) 10mg/kg ip. Extracellular concentration of hydroxyl radical was measured using microdialysis in freely moving mice and was assayed by HPLC with electrochemical detection. MDMA dose-dependently increased production of hydroxyl radical in the mouse striatum and its effect was reversed by caffeine. The data show that caffeine may have neuroprotective properties as it decreased oxidative stress induced by MDMA.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 10
- The Role of Adenosine A1 and A2A Receptors in the Caffeine Effect on MDMA-Induced DA and 5-HT Release in the Mouse Striatum Neurotoxicity Research November 13, 2014
- Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats International Journal of Molecular Sciences March 12, 2019
- Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings Neural Regeneration Research February 22, 2024
- The effect of repeated-intermittent exposure to 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) during adolescence on learning and memory in adult rats. Pharmacological Reports October 1, 2018
- In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice. Neurotoxicology March 2021
and 5 more in the library
Cites 4
- Amphetamine toxicities Annals of the New York Academy of Sciences January 8, 2010
- Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview Molecular Neurobiology June 1, 2009
- Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love"). Neuropharmacology January 2006
- The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. Journal of Pharmacology and Experimental Therapeutics May 1, 1995