Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats
Brian J. Piper, Christina S. Henderson, Jerrold S. Meyer
Developmental Psychobiology July 1, 2014 DOI: 10.1002/dev.21169 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Female Sprague-Dawley rats |
| Intervention | MDMA |
| Dose | 10 mg/kg × 2 for pretreatment, 5 mg/kg × 4 for binge |
| Duration | From postnatal day 35 to 60 for pretreatment, with binge on postnatal day 67 |
| Topics | MDMA |
| Citations | 2 |
| Key findings | Prior intermittent MDMA pretreatment blocked the reductions in serotonin transporter binding and temperature dysregulation induced by an MDMA binge in female rats, but unlike males, motor activity was not reduced by the binge. |
Abstract
AbstractIntermittent MDMA pretreatment blocked the reductions in serotonin transporter (SERT) binding induced by an MDMA binge in a prior study in adolescent male rats. The objective of this investigation was to determine if the physiological, behavioral, and neurochemical responses to MDMA are sexually dimorphic. Female Sprague–Dawley rats received MDMA (10 mg/kg × 2) or Saline on every fifth day from postnatal day (PD) 35–60 and an MDMA binge (5 mg/kg × 4) on PD 67. The MDMA binge induced a pronounced temperature dysregulation in MDMA‐naïve, but not MDMA‐pretreated, groups. Similarly, MDMA‐pretreated animals were resistant to the binge‐induced SERT reductions, especially in the hippocampus. Motor activity at PD 68 was not reduced by the binge, unlike the responses found in males. These results show that female rats differ from males in their responses to an MDMA binge but are similar with respect to preconditioning from prior MDMA exposure. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 924–934, 2014.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 23
- Gender differences in the subjective effects of MDMA Psychopharmacology March 5, 2001
- Sub-acute effects of MDMA (±3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences Psychopharmacology April 1, 2002
- Death rates from ecstasy (MDMA, MDA) and polydrug use in England and Wales 1996–2002 Human Psychopharmacology: Clinical and Experimental September 19, 2003
- Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model* Critical Care Medicine June 1, 2005
- Repeated MDMA (“Ecstasy”) exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding Developmental Psychobiology 2005
and 18 more in the library