World Journal of Advanced Research and Reviews
April 30, 2026
Khalfy Y. El, Chhaiba Y. Ould, Andaloussi Y. El
Background: 3,4-methylenedioxymethamphetamine (MDMA), or "Ecstasy," is a semi-synthetic stimulant and hallucinogen widely used recreationally. While known for producing euphoria, it is associated with severe medical complications including serotonin syndrome, rhabdomyolysis, and multi-organ failure. Although MDMA is known to cause various vascular and muscular lesions, deep venous thrombosis...
Preprints.org
April 29, 2026
Stefano Marini, Domenico de Berardis
preprint
Psychedelic drugs are serotonergic hallucinogens that can be divided into two types: naturally occurring (psilocybin, psilocin, and N,N-dimethyltryptamine) and synthetic (LSD, MDMA, 2,5-dimethoxy-4-iodoamphetamine, and ketamine). Psychedelics generally work on 5-hydroxytryptamine receptors and might be useful in cognitive enhancement, brain connectivity, neuroplasticity, and neuronal...
Pflügers Archiv: European Journal of Physiology
April 23, 2026
Ayodeji Folorunsho Ajayi, David Tolulope Oluwole, Moses Agbomhere Hamed et al.
3,4-Methylenedioxymethamphetamine (MDMA), a synthetic psychoactive amphetamine derivative widely abused as the recreational drug “ecstasy,” is associated with oxidative stress–mediated cardiotoxicity and hematological disturbances. Despite documented antioxidant properties of quercetin and vitamin E individually, limited evidence exists regarding their combined protective efficacy against...
BMC Pharmacology and Toxicology
April 11, 2026
O O Obembe, E T George, R A Mustapha et al.
BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) is a psychostimulant known for its social and empathogenic effects. However, its long-term impact on sexual performance and reproductive functions remain controversial. OBJECTIVE: In this study, the effects of chronic MDMA exposure and subsequent withdrawal on sexual behaviour, reproductive hormones, sperm parameters, oxidative stress,...
Molecular Psychiatry
April 8, 2026
Johannes G. Ramaekers, Kim P. C. Kuypers, Franz X. Vollenweider
1 citation
MDMA's history spans military experimentation, recreational use, and clinical trials for PTSD treatment, reflecting both promise and controversy. While studies in heavy users suggested possible neurotoxicity, evidence remains inconclusive. Clinical trials show that one to three sessions of MDMA-assisted psychotherapy can alleviate PTSD symptoms, yet regulators have criticized inadequate...
Annals of Medicine and Surgery
April 6, 2026
Mahnoor Sheikh, Zaibunnisa Bilal, Syeda Habiba Fatima et al.
To the Editor, Autism spectrum disorder (ASD) is a neurodevelopmental state in which there are early emerging problems in social communication along with fixed behavior patterns. Social difficulties in ASD are characterized by difficulty in interpretation of interpersonal signals such as facial expressions, tone of voice, and body language. Individuals with ASD often present with social...
Journal of Psychopharmacology
April 6, 2026
Kirsten L Rock, Paul Rees, David Morgan et al.
3,4-methylenedioxymethamphetamine (MDMA) is being investigated as a new therapy for post-traumatic stress disorder (PTSD). With antidepressants as the first-line pharmacotherapy for PTSD, it is important to understand any drug-drug interactions between antidepressants and MDMA. This study aimed to investigate the association between antidepressant use and MDMA fatality using a drug-death...
Quality in Sport
April 5, 2026
Magdalena Ostaszewska, Milena Majchrzyk, Damian Zienkiewicz et al.
Introduction and aim of the study: 3,4-methylenedioxymethamphetamine (MDMA) is a stimulant drug with widespread consumption. It is used mainly in recreational settings, due to its ability to induce various pleasurable, mood-enhancing effects. Prolonged and excessive MDMA misuse can lead to multiple negative outcomes ranging from cognitive dysfunction or emotional dysregulation to severe...
Drugs
April 1, 2026
Martha S. Rosenthal
This chapter examines the pharmacology, effects, and history of stimulants, focusing on cocaine, amphetamines, MDMA, and other related substances. Cocaine plays a significant role as a medical marvel and recreational drug, available in forms such as powder and crack, which differ in potency and methods of use. Amphetamines, initially praised for their therapeutic benefits, gain attention for...
JME Practical Bioethics
April 1, 2026
Christoph Bublitz
The application for MDMA-assisted therapy (MDMA-AT) and its rejection by the FDA in 2024 prompted a debate about ethical aspects in drug regulation. This paper examines central issues raised in that debate through the lens of human rights, especially the right to health. It argues that drug approval decisions must take into account the multipolar constellation of and dependencies between...