Psychopharmacology
March 4, 2026
Ava M. Mac, Srinivasu Kallakuri, Alixandria T. Mascarin et al.
MDMA (3–4 methylenedioxymethamphetamine) assisted psychotherapy has gained considerable attention as a potential adjuvant therapy for post-traumatic stress disorder (PTSD). Reports of the nonmedical use of MDMA suggest its adverse effects may include anxiety and anhedonia. However, the time course of these signs and symptoms and the potential alterations in neurotransmitter levels that may...
Drug and Alcohol Review
March 1, 2026
Jack Freestone, Harriet MacDonald, Stassi Kypri et al.
Drug alerts are sometimes issued when samples are found to exceed a pre-determined dose threshold. In Australia, it is common for alerts to be issued when MDMA pills contain ≥ 150 mg of MDMA free-base or 179 mg hydrochloride. Nineteen such alerts were issued in Australia in 2024, raising concerns that repeat alerts may lose impact over time. This study examined experts' viewpoints on the...
Pharmacology, Biochemistry, and Behavior
March 1, 2026
Negar G Ardabili, Shira Tan, María Elisa Márquez De Prado Arrarás et al.
Both the rewarding and aversive effects of a drug contribute to its abuse potential. One factor known to impact the balance of these effects is concurrent and serial polydrug use. A drug class for which such interactions are common is synthetic cathinones. In prior work, history with the synthetic cathinone eutylone had no effect on cocaine- or MDMA-induced taste avoidance in male rats,...
February 24, 2026
Momoko Ishii, Mark Zervas
S elective S erotonin R euptake I nhibitors (SSRIs) and two psychedelics, Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine), and MDMA (3,4-Methylenedioxymethamphetamine) act on serotonergic-related neural circuits and function as serotonin modulators. All three molecules are either currently used or proposed as novel therapeutic modalities to treat P ost- T raumatic S tress D isorder (PTSD)....
Translation The University of Toledo Journal of Medical Sciences
February 17, 2026
Amy Hooper, Evelyn K. Lambe
MDMA-assisted psychotherapy has emerged as a promising treatment for post-traumatic stress disorder (PTSD), particularly in individuals unresponsive to conventional interventions such as SSRIs and trauma-focused cognitive behavioral therapy. As recent clinical trials report durable symptom remission, ongoing debate surrounds the mechanisms underlying its therapeutic effects. This review...
Journal of Forensic Sciences
February 12, 2026
Thomas Sheehan, Hilary J Hamnett, Sarah G. G. Russell et al.
3,4-Methylenedioxymethamphetamine (MDMA) or "ecstasy," is a commonly used drug worldwide, including in New Zealand, where 4.8% of the population aged 15 years or over reported using it in a 2023/2024 survey. This study provides additional insights on MDMA prevalence data in New Zealand by reporting toxicology data from Coronial and driving under the influence of drugs (DUID) cases positive for...
The British Journal of Psychiatry
February 10, 2026
Tor-Morten Kvam, Ivar W Goksøyr, Justyna Rog et al.
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Scientific Reports
February 10, 2026
Michelle Olofsson, Kasim Acar, Otto Simonsson et al.
Recent research has highlighted the potential of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for the treatment of post-traumatic stress disorder and other trauma-related psychiatric conditions. However, less is known about the effects of MDMA use on psychological well-being in populations with trauma histories outside of clinical contexts. In the present study, we assessed...
Behavioural Brain Research
February 10, 2026
Kristin A. Felsch, Jessica A. Siegel
3,4-methylenedioxymethamphetamine (MDMA) is a psychomotor stimulant drug. While much research has examined the effects of MDMA in adults, relatively little research has examined the effects in adolescents. Adolescence is a unique period of brain development, and the effects of MDMA may differ in adolescents compared to adults. In this review, we summarize the literature on the effects of acute...
International Journal of Electrochemical Science
February 9, 2026
Anne Felim, Anne Neudörffer, François P. Monnet et al.
A straightforward one-pot electrochemical synthesis of bis-catechol-thioether metabolites of MDMA (ecstasy), 2,5-bis(glutathion-S-yl)-N-methyl-α-methyldopamine and 2,5-bis(N-acetylcystein-S-yl)-N-methyl-α-methyldopamine, in acceptable yields and high degree of purity (99%), is described under environmentally friendly conditions. The undeniable benefits of this method, which uses...