Neuropsychopharmacology
June 2005
Grégory Conductier, Cyril Crosson, René Hen et al.
3,4-Methylenedioxy-N-methamphetamine (MDMA or 'ecstasy') is a psychoactive substance, first described as an appetite suppressant in humans, inducing side effects and even death. MDMA increases serotonin (5-HT) levels, and 5-HT inhibits food intake, but the 5-HT receptors involved in MDMA-induced changes in feeding behavior are unknown. We examined whether a systemic MDMA injection would reduce...
American Journal of Health-System Pharmacy
February 1, 2005
Peter J. Zed
1 citation
Drug and substance abuse is a major problem in North America. Health care providers who care for patients who abuse drugs and other substances need to have a clear understanding of the health, societal, and economic impact of this problem and an intimate knowledge of the agents of abuse to ensure adequate treatment. Pagliaros' Comprehensive Guide to Drugs and Substances of Abuse was written to...
Substance Use & Misuse
2005
Jill A. McCaughan, Robert G Carlson, Rüssel S. Falck et al.
43 citations
Although young people attending raves have been most visibly associated with the use of ecstasy and other "club drugs" in the United States, there is reason to believe that they are not a homogenous group in terms of their drug use practices. The purpose of this article is to begin developing a typology of young adult ecstasy users involved in the rave subculture--known as Ravers or Party Kids....
Journal of Chromatography B
November 25, 2004
Helena Carmo, Douwe De Boer, Fernando Remião et al.
32 citations
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS...
Journal of Psychoactive Drugs
September 2004
Kathleen A Parks, Cheryl L Kennedy
This preliminary descriptive study was designed to assess the reasons, primary contexts, and consequences (physical, psychological, lifestyle) of club drug use in a sample of young adults in a mid-size U.S. city. Fifty young adults (18 to 30 years old) reported on their use of club drugs (Ecstasy, GHB, ketamine, Rohypnol, methamphetamine, LSD) in face-to-face interviews that included...
Toxicology
August 5, 2004
Márcia Carvalho, Fernando Remião, Nuno Milhazes et al.
In the past decade, clinical evidence has increasingly shown that the liver is a target organ for 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") toxicity. The aims of the present in vitro study were: (1) to evaluate and compare the hepatotoxic effects of MDMA and one of its main metabolites, N-methyl-alpha-methyldopamine (N-Me-alpha-MeDA) and (2) to investigate the ability of antioxidants,...
Educational Media Reviews Online
May 21, 2004
L. Widzinski
Distributed by Human Relations Media, 41 Kensico Drive, Mt. Kisco, NY 10549; 800-431-2050Produced by John O'NeilDirected by John O'Neil2003, VHS, color, 18 min. LSD, mushrooms, mescalin, psilocybin – classic auditory and visual hallucinogens, and probably the best known of hallucinogenic drugs due to the 1960s counterculture. These and newer, more potent hallucinogens are profiled in this HRM...
Toxicology and Applied Pharmacology
April 15, 2004
Andrés Jiménez, Elvira G Jordà, Ester Verdaguer et al.
The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) on cerebellar granule neurones (CGNs) culture was examined. Treatment for 48 h with METH or MDMA (1-5 mM) induced a higher decrease in viability than 24 h treatment. z.VAD.fmk (100 microM) but not MK-801 nor NBQX recovered control viability values. In both cases, cell death was...
Sosiaalilääketieteellinen Aikakauslehti
February 1, 2004
Mikko Salasuo
Ecstasy is the trend drug of the 1990's. Its use spread among the so-called techno and rave culture from Great Britain from the late 1980's to all western countries. Even the phenomenon is quite new; the substance was already found as early as 1912 in Germany. The substance was not taken into use until early 1950's, when the U.S military tested possibilities to use it for military purposes. It...
Archives of Toxicology
January 2004
Márcia Carvalho, Nuno Milhazes, Fernando Remião et al.
The amphetamine designer drugs 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and its N-demethylated analogue 3,4-methylenedioxyamphetamine (MDA or "love") have been extensively used as recreational drugs of abuse. MDA itself is a main MDMA metabolite. MDMA abuse in humans has been associated with numerous reports of hepatocellular damage. Although MDMA undergoes extensive hepatic...