British Journal of Pharmacology
May 2008
Iain S. Mcgregor, P D Callaghan, G E Hunt
Addictive drugs can profoundly affect social behaviour both acutely and in the long-term. Effects range from the artificial sociability imbued by various intoxicating agents to the depressed and socially withdrawn state frequently observed in chronic drug users. Understanding such effects is of great potential significance in addiction neurobiology. In this review we focus on the 'social...
Talanta
January 15, 2008
Bo-Hong Chen, Ju-Tsung Liu, Wen-Xiong Chen et al.
32 citations
Certain characteristic fragmentations of tryptamines (indoleethylamine) and phenethylamines are described. Based on the GC-EI/MS, LC-ESI/MS and MALDI/TOFMS, the mass fragmentations of 13 standard compounds, including alpha-methyltryptamine (AMT), N,N-dimethyltryptamine (DMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT),...
Journal of ethnicity in substance abuse
2008
Kit Sang Leung, Jih-Heng Li, Wen-Ing Tsay et al.
Research among Asian users of methylenedioxy methamphetamine (MDMA), also known as Ecstasy, is rare. To evaluate the feasibility of a study on the abuse of and dependence on Ecstasy, two focus groups of users (n= 12) and health professionals (n=7) were conducted in Taiwan. Major results included blatant human testing with "candy and dinosaur girls" and a specific sequence of drugs called a...
Pharmacology, Biochemistry, and Behavior
January 2008
William E Fantegrossi, Chad J Reissig, Elyse B Katz et al.
N,N-dipropyltryptamine (DPT) is a synthetic tryptamine hallucinogen which has been used psychotherapeutically in humans, but has been studied preclinically only rarely. In the present studies, DPT was tested in a drug-elicited head-twitch assay in mice, and in rats trained to discriminate lysergic acid diethylamide (LSD), N,N-dimethyl-4-phosphoryloxytryptamine (psilocybin), or...
Pharmacology, Biochemistry, and Behavior
January 2008
Jerrold C Winter
It has been observed that agents with agonist activity at 5-HT2A receptors prevent neurotoxicity induced by the non-competitive NMDA antagonist, dizocilpine (MK-801). Subsequent behavioral studies reported complete antagonism by LSD and DOM of the stimulus effects of the related NMDA antagonist, phencyclidine [PCP]. The present study sought to extend those observations to include other...
Proceedings of the National Academy of Sciences
October 9, 2007
Alexandra Jean, Grégory Conductier, Christine Manrique et al.
Anorexia nervosa is a growing concern in mental health, often inducing death. The potential neuronal deficits that may underlie abnormal inhibitions of food intake, however, remain largely unexplored. We hypothesized that anorexia may involve altered signaling events within the nucleus accumbens (NAc), a brain structure involved in reward. We show here that direct stimulation of serotonin...
Pharmacology, Biochemistry, and Behavior
October 1, 2007
Jerrold C Winter, K C Rice, D J Amorosi et al.
73 citations
Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of psilocybin was observed following...
July 4, 2007
A. Powell
Deleuze, Altered States and Film offers a typology of altered states, defining dream, hallucination, memory, trance and ecstasy in their cinematic expression. The book presents altered states films as significant neurological, psychological and philosophical experiences. Chapters engage with films that simultaneously present and induce altered consciousness. They consider dream states and the...
The Beauty of the Primitive
July 1, 2007
Andrei A. Znamenski
1 citation
Abstract The increased attention given to shamanism in humanities studies and in popular culture since the 1960s is usually associated with two names: Mircea Eliade and Carlos Castaneda. Eliade, a Romanian-born philosopher and religious scholar, released Le Chamanisme et les techniques archaiques de l'extase, the first grand treatise on shamanism, which became an academic bestseller after its...
Drug and Alcohol Dependence
March 16, 2007
Andrea L Stone, Megan S O'Brien, Alejandro De la Torre et al.
This study, based upon epidemiological survey data from the United States (U.S.) National Household Surveys on Drug Abuse (NHSDA) from 2000 to 2001, presents new estimates for the risk of developing a hallucinogen dependence syndrome within 24 months after first use of any hallucinogen (median elapsed time approximately 12 months). Subgroup variations in risk of becoming hallucinogen dependent...