Human Psychopharmacology: Clinical and Experimental
October 1, 2003
Suzanne L. Verheyden, John A. Henry, Helen Valerie Curran
171 citations
Abstract This study examined the reported psychological effects of different patterns of MDMA use in men and women, and how they are modified by use of other psychoactive substances. A semi‐structured interview was conducted with 466 regular MDMA users, exploring the perceived acute, sub‐acute and long‐term subjective effects of this drug. Factor analysis established three main categories of...
Psychiatry Research
September 30, 2003
Gilberto Gerra, Sara Bassignana, Amir Zaimovic et al.
Fifteen 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') users who did not have other drug dependencies or prolonged alcohol abuse and 15 control subjects were studied. All the subjects were exposed to the same psychosocial stressor (Stroop Color-Word Interference Task, public speaking and mental arithmetic in front of an audience) 3 weeks after MDMA discontinuation. Plasma concentrations of...
Human Psychopharmacology: Clinical and Experimental
September 19, 2003
Fabrizio Schifano, Adenekan Oyefeso, John Corkery et al.
93 citations
Abstract The present study reports on all deaths related to taking ecstasy (alone, or in a polydrug combination) occurring in England and Wales in the time frame August 1996–April 2002. Data presented here are based on all information recorded in the National Programme on Substance Abuse Deaths (np‐SAD) database. The np‐SAD regularly receives all information on drug related deaths in addicts...
Pharmacological Reviews
September 2003
Alfred Richard Green, Annis O. Mechan, J Martin Elliott et al.
The amphetamine derivative (+/-)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a popular recreational drug among young people, particularly those involved in the dance culture. MDMA produces an acute, rapid enhancement in the release of both serotonin (5-HT) and dopamine from nerve endings in the brains of experimental animals. It produces increased locomotor activity and the serotonin...
Anthropology of Consciousness
September 1, 2003
Evajane N. Fridman
21 citations
Nine Worlds of SEID‐MAGIC: Ecstasy and Neo‐Shamanism in North European Paganism. Jenny Blain. London and New York: Routledge, 2001. 192 pages $20.95 Paperback.
Pediatric nephrology
August 2003
Charles Kwon, Arno Zaritsky, Vikas R Dharnidharka
Multiple renal adverse effects have been anecdotally reported with the ingestion of 3,4-methylenedioxymethamphetamine (Ecstasy), a widely used recreational drug. These side effects include acute renal failure, necrotizing vasculitis, and hyponatremia, the mechanisms for which are unknown. We report a case of transient acute proximal tubular injury and hyponatremia associated with Ecstasy use....
Nitric oxide : biology and chemistry
August 2003
Karen L. Anderson, Yossef Itzhak
Repeated exposure to psychostimulants such as cocaine and amphetamines results in behavioral sensitization, a paradigm thought to be relevant to drug craving and addiction in humans. We have previously shown that the induction, expression, and maintenance of psychomotor sensitization to cocaine, methamphetamine, and methylphenidate (indirect dopamine agonists) are blocked by co-administration...
The American journal of the medical sciences
August 2003
Milos N Budisavljevic, Lisa Stewart, Steven A Sahn et al.
We present a case of acute, symptomatic hyponatremia in a young woman that developed after use of 3,4-methylenedioxymethylamphetamine (MDMA), more commonly known as "ecstasy." The patient was treated with 5% saline and had complete recovery. The pathogenesis of MDMA-associated hyponatremia involves excessive water intake and inappropriately elevated antidiuretic hormone (ADH) levels. It seems...
Journal of Neural Transmission
July 1, 2003
H B Lebsanft, Andreas Mayerhofer, Karl-A Kovar et al.
3,4-Methylenedioxymethamphetamine (MDMA) has recently been hypothesized to be effective against the symptoms of Parkinson's disease. Therefore we tested the effects of MDMA-derivatives in the rotational behavioural model. Male Sprague Dawley rats were lesioned unilaterally with 6-hydroxydopamine at the medial forebrain bundle. MDMA was administered at doses of 2.5, 5.0 and 10.0 mg/kg, its...
Molecular Pharmacology
June 2003
Vincent Setola, Sandra J Hufeisen, K Jane Grande-Allen et al.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia [valvular heart disease (VHD)] and primary pulmonary hypertension observed in patients taking the now-banned appetite suppressant fenfluramine (Pondimin, Redux). Via large-scale, random screening of a portion of the receptorome, we have discovered that the amphetamine...