Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-methylenedioxymethamphetamine (Ecstasy) in rats: role of drug context.
Neuroscience September 25, 2010 DOI: 10.1016/j.neuroscience.2010.09.041 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Topics | MDMA |
| Key findings | Repeated MDMA administration induces behavioral sensitization and alters striatal electrophysiology and structure, with drug context playing a modulatory role in these neural changes. |
Abstract
Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-methylenedioxymethamphetamine (Ecstasy) in rats: role of drug context.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 6
- Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine Toxicology Reports October 11, 2016
- Prelimbic medial prefrontal cortex has bidirectional control over the expression of behavioral sensitization to 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) depending on the context of drug administration. Neuroscience Letters June 4, 2022
- Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA ('Ecstasy') Substance Use Disorder. Current Topics in Behavioral Neurosciences 2017
- Yohimbine reinstates extinguished 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) seeking in rats with prior exposure to chronic yohimbine. Behavioural Brain Research November 1, 2015
- Tolerance to the locomotor-activating effects of 3,4-methylenedioxymethamphetamine (MDMA) predicts escalation of MDMA self-administration and cue-induced reinstatement of MDMA seeking in rats. Behavioural Brain Research November 1, 2014
and 1 more in the library
Cites 4
- Problematic versus non-problematic ecstasy/MDMA use: the influence of drug usage patterns and pre-existing psychiatric factors Journal of Psychopharmacology March 30, 2006
- Context‐dependent behavioural and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats European Journal of Neuroscience July 1, 2006
- Sensitizing regimens of (+/-)3, 4-methylenedioxymethamphetamine (ecstasy) elicit enduring and differential structural alterations in the brain motive circuit of the rat. Neuroscience May 5, 2009
- Reinstatement of MDMA (ecstasy) seeking by exposure to discrete drug-conditioned cues. Pharmacology, Biochemistry, and Behavior October 2007