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Acute MDMA administration alters the distribution and circadian rhythm of wheel running activity in the rat.

Brain Research September 26, 2010 DOI: 10.1016/j.brainres.2010.08.094 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational study Peer reviewed
Population Rats
Intervention MDMA
Topics MDMA
Key findings Acute MDMA administration alters the distribution and circadian rhythm of wheel-running activity in rats, indicating that MDMA acutely disrupts normal activity patterns.

Abstract

Acute MDMA administration alters the distribution and circadian rhythm of wheel running activity in the rat.

Comparable studies

Other preclinical and animal studies on MDMA, most cited first.

Study Year Design Participants
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) 1987 Experimental study
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain 1987 Animal experiment
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells 2006 In vitro laboratory study
Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Rats 1998 Experimental study
Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery Squirrel monkeys treated with MDMA 1999 Observational cohort

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