Archives of Neurology And Psychiatry
May 1, 1951
Gordon R. Forrer
66 citations
STOLL1studied the effects of lysergic acid diethylamide (LSD-25) in both psychotic and normal subjects. Condrau2and others reported their results of administration of lysergic acid diethylamide to various types of subjects and in general confirmed the findings of Stoll. For details of the chemistry of the ergot alkaloids, we refer to a more recent, comprehensive work by Stoll.3It should be...
American Journal of Therapeutics
Bryce D. Beutler, Kenneth Shinozuka, Burton J. Tabaac et al.
11 citations
Lysergic acid diethylamide (LSD) is a hallucinogenic agent. In the mid-20th century, it was used to augment psychoanalysis and to treat alcohol use disorder. However, LSD was banned in 1970 in part because of concerns that it could bring about or exacerbate mental illness. Its therapeutic potential remains incompletely understood. While uncontrolled recreational use of LSD can, in rare...
Brandy Disbennett
preprint
Currently, veterans who were harmed by the top-secret Vietnam-era CIA program, MKULTRA, that exposed unwitting armed forces’ service-members to LSD, lack any remedy either in court or through the Department of Veterans Affairs disability compensation system. Veterans who received doses of LSD without giving their consent are deprived of their right to due process in the court system, and cannot...
Niccolo Leo Caldararo
preprint
In the 1960s and 1970s LSD began to be used as a potential therapeutic agent by a number of researchers. The author participated in a number of studies of perception, including sensory deprivation and psychotropic drugs, some of recent manufacture or discovery and some of primitive or traditional societies. This paper summarizes the experiences and research of the author from that time and a...
Lila Harris, Zachary Smith, Richard J. Ortiz et al.
preprint
Abstract Background: LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. Methods: Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by...
Fahd François Hilal, Rayane Benkeddada, Jeanblanc Jérôme et al.
Background Classical psychedelics induce profound changes in brain function, yet the temporal organization of these effects remains incompletely understood. Methods We investigated the effects of acute lysergic acid diethylamide (LSD) on large-scale brain connectivity in nine male Long–Evans rats using resting-state functional magnetic resonance imaging. Following a 15-min baseline acquisition,...
Research Square
Ulrich Gergs, Hannes Jacob, Pauline Braekow et al.
1 citation
preprint
Abstract Introduction: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. Methods: We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice...
ChemRxiv
Sarah A. Shuda
1 citation
preprint
Lysergic acid diethylamide (LSD) and analogs are psychedelic drugs commonly submitted to forensic chemistry laboratories. These drugs are often present on items of evidence at low concentrations, requiring sensitive analyses to positively identify their presence. The injection port of a gas chromatograph (GC) plays an important role in vaporizing and transferring substances to the column for...
Bryce D. Beutler, Kenneth Shinozuka, Burton J. Tabaac et al.
preprint
Background: Lysergic acid diethylamide (LSD) is a hallucinogenic agent. In the mid-20th century, it was used to augment psychoanalysis and to treat alcohol use disorder. However, LSD was banned in 1970 in part due to concerns that it could bring about or exacerbate mental illness. Its therapeutic potential remains incompletely understood.Areas of Uncertainty: While uncontrolled recreational use...
Journal of Psychopharmacology
October 27, 2026
José Augusto Silva Reis, Lara Zancaner Ueta, José Carlos Bouso et al.
This systematic review evaluates the relationship between classical psychedelic drugs (D-Lysergic acid N,N-diethylamide, psilocybin, ayahuasca/N-N-dimethyl-tryptamine, and mescaline) and the emergence of psychotic symptoms, aiming to synthesize evidence from contemporary studies (1984-2025) regarding the risk factors, prevalence, and clinical characteristics of psychosis related to psychedelic...