Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition.
Tomáš Páleníček, Zdenek Hlinák, Vĕra Bubeníková‐valešová, Tomáš Novák, Jiří Horáček
Progress in Neuro-Psychopharmacology and Biological Psychiatry May 30, 2010 DOI: 10.1016/j.pnpbp.2010.02.008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Rats (males, oestral/pro-oestral females, metoestral/dioestral females) |
| Intervention | LSD |
| Dose | 5, 50, and 200 microg/kg subcutaneously |
| Measures | prepulse inhibition (PPI) of the acoustic startle reaction, open field behavioral repertoire |
| Topics | LSD |
| Key findings | LSD reduced locomotion and disrupted PPI in males and metoestral/dioestral females, but oestral/pro-oestral females were protected from PPI disruption and showed increased locomotion later in testing, indicating lower sensitivity to LSD's behavioral effects. |
Abstract
The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and metoestral and dioestral phase females (MD females). LSD (5, 50 and 200 microg/kg subcutaneously) attenuated locomotor activity and normal behavioural repertoire, and induced flat body posture, wet dog shakes and disrupted PPI. The most prominent behavioural findings of LSD were for LSD 200 microg/kg which suppressed almost all behavioural activity. LSD had mainly inhibitory locomotor effects in males and MD females, yet in EP female rats LSD increased locomotion during the second half of testing period. The main sex differences were observed in locomotor and exploratory behaviour. Both EP and MD females were less sensitive to hypolocomotor effects of LSD and had less pronounced thigmotaxis than males. Further EP females had increased rearing after LSD 5microg/kg. On the contrary although LSD disrupted PPI in males and MD female rats, EP females were protected from this disruptive effect. Thus, EP females seem to have a lower sensitivity to LSD behavioural actions.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 42
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
- Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression ACS Chemical Neuroscience March 5, 2020
- Effect of Hallucinogens on Unconditioned Behavior Current Topics in Behavioral Neurosciences 2016
- LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1 Scientific Reports September 5, 2021
- Sex differences and serotonergic mechanisms in the behavioural effects of psilocin Behavioural Pharmacology October 13, 2015
and 37 more in the library
Cites 31
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Neuroreport December 1, 1998
- Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose?effect study Psychopharmacology March 1, 2004
- Gender differences in the subjective effects of MDMA Psychopharmacology March 5, 2001
- Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers Pharmacopsychiatry November 1, 2005
and 26 more in the library