Psychiatric and neurodegenerative illnesses are characterized by cognitive impairments, in particular deficits in working memory, decision making, and executive functions including cognitive flexibility. However, the neuropharmacology of these cognitive functions is poorly understood. The serotonin (5-HT) 2A receptor might be a promising candidate for the modulation of cognitive processes....
Psychedelics exert unique effects on human consciousness. The thalamic filter model suggests that core effects of psychedelics may result from gating deficits, based on a disintegration of information processing within cortico-striato-thalamo-cortical (CSTC) feedback loops. To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after...
Revista Texto PoéticoJanuary 25, 2019Fernanda Vivacqua de Souza Galvão Boarin, Alexandre Graça Faria
O presente artigo apresenta uma leitura do relato Experiência com LSD, do poeta, cronista e tradutor brasileiro Paulo Mendes Campos, escrito originalmente em 1962. Para tanto, recorre-se às relações dialógicas encontradas no texto, a exemplo de As portas da percepção: e céu e inferno (1954), de Aldous Huxley, tendo como objetivo compreender não apenas as formulações de Campos sobre a...
Abstract Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers in-vestigating the neural origins of consciousness. Currently, the most compelling theories of how psychedelics exert their effects is by increasing the complexity of brain activity and moving the system towards a critical point between order and disorder, creating more dynamic and complex patterns of...
Erythema multiforme major (EMM) is a severe hypersensitivity skin reaction that is potentially life threatening. We present a case report of a gentleman who presented with EMM induced by Lysergic acid diethylamide. The case aims to raise awareness and highlights the importance of taking a comprehensive drug history including recreational drug use. This is especially important in the face of...
Abstract Although less common than abuse of marijuana and cocaine, abuse of magic mushroom, peyote cactus, lysergic acid diethylamide (LSD), khat, and volatiles is observed in the United States. Eating wild mushroom is dangerous because misidentification of toxic mushroom as magic mushroom may be fatal. Magic mushroom contains psilocybin and psilocin but major psychedelic action of magic...
Reviewed by: The Trials of Psychedelic Therapy: LSD Psychotherapy in America by Matthew Oram Nicolas Rasmussen Matthew Oram. The Trials of Psychedelic Therapy: LSD Psychotherapy in America. Baltimore: Johns Hopkins University Press, 2018. xiv + 269 pp. Ill. $49.95 (978-1-4214-2620-4). The colorful history of the hallucinogen LSD has attracted the attention of numerous historians of medicine,...
\n Depois de apresentar as origens históricas da contracultura, no Brasil e nos Estados Unidos, e contextualizar um pouco das relações entre os integrantes destes movimentos e o uso de drogas, sobretudo maconha e ácido lisérgico, esse trabalho traça, através principalmente da análise de trajetórias individuais que se cruzam de uma forma ou de outra, uma história social da chegada do LSD ao...
RATIONALE: Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects...
As a classical hallucinogen with high potential for abuse, lysergic acid diethylamide (LSD) can cause long-lasting abnormalities in retina, but little is known about the exact mechanism. This study was to investigate effects of long-term systemic treatment of LSD at low dose on retinal damage and understand the underlying mechanisms. CD1 mice were treated intraperitoneally with 0.1 mg/kg or 0.2...