Salvia divinorum is a member of the Lamiaceae family and contains the psychotropic diterpene and kappa-opioid receptor agonist salvinorin-A. Originally a shamanic inebriant used by the Mexican Mazatec Indians, the plant and its preparations are becoming increasingly popular among non-traditional users. Demographic data and information on pattern of use and subjective effects were obtained by...
To the Editor.—Dextromethorphan is the d-isomer of the codeine analog, levorphanol, and the active ingredient in >100 over-the-counter cough and cold preparations. Reports of dextromethorphan abuse date back to the 1960s.1,2 There is some evidence suggesting that when used inappropriately at very high doses (eg, 1500 mg/day), dextromethorphan can result in a dependence-like syndrome.2...
This manuscript reviews the history and pharmacognosy of ergot, and describes the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives. A brief discussion of the hallucinogenic properties of lysergic acid diethylamide is also featured. An abbreviated form of the material found in this paper is presented in a 4-hour...
In the late 1960s, the University College Literary and Athletic Society (the Lit) sponsored three festivals devoted to “Pop” art, psychedelia, and propaganda. As part of the 1967 festival, the Lit unsuccessfully attempted to have Timothy Leary visit to discuss the usefulness of LSD. This paper explores the festivals at University College, the controversy they created, and their successes and...
Afrique & histoireSeptember 15, 2006Patricia A. Helvenston, Paul G. Bahn1 citation
Résumé Cet article oppose une série de contradictions au modèle neuropsychologique dit des Trois Stades de la Transe (TST) proposé par Lewis-Williams et Dowson, modèle dont la popularité excède de loin la solidité de ses fondations empiriques. Lewis-Williams et Dowson ont écrit comme si le modèle TST avait été vérifié en Afrique du Sud, mais ce n’est pas le cas, ainsi que nous le montrons par...
Abstract This study uses latent class methods and multiple regression to shed light on hypothesized hallucinogen dependence syndromes experienced by young people who have recently initiated hallucinogen use. It explores possible variation in risk. The study sample, identified within public‐use data files of the 1999 National Household Survey on Drug Abuse (NHSDA), consists of 1186 recent‐onset...
The book is a collection of interviews and the distilled wisdom obtained between late 1996 and mid-1998, updated and edited by eminent psychiatrists, Professors Roger Walsh and Charles Grob. The alliteratively poetic title in lower case, in green and blue with a colorful psychedelic logo, contrasts with the ashen photographs of all the participants. The book will evoke nostalgia in anyone who...
A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was designed using a 5-HT(2A) receptor homology model. The compound possessed 3-fold higher affinity and potency than and efficacy equal to that of mescaline at the 5-HT(2A) receptor. The new analogue substituted fully for LSD in drug discrimination studies and was 5-fold more potent than mescaline....
Psychedelic drugs such as LSD and psilocybin are often claimed to be capable of inducing life-changing experiences described as mystical or transcendental, especially if high doses are taken. The present study examined possible enduring effects of such experiences by comparing users of psychedelic drugs (n = 88), users of nonpsychedelic illegal drugs (e.g., marijuana, amphetamines) (n = 29) and...
Abstract Simultaneous polysubstance use (SPU) is a common phenomenon, yet little is known about how various substances are used with one another. In the present study 149 drug‐using university students completed structured interviews about their use of various substances. For each substance ever used, participants provided details about the type, order and amount of all substances...