Drugs and Alcohol Today
July 1, 2007
Casey Hardison
2 citations
Casey Hardison was arrested in spring 2004 for the production of psychedelictype drugs ie. LSD, 2C‐B and DMT. In the three years since, not one person from ‘authority’ had bothered to ask him what motivated him to synthesise psychedelic drugs. It was as if the a priori assumption that ‘all illegal drugs are bad’ had provided the answer. Hence, the Judge asserted that Hardison did it for ‘that...
Proceedings of the National Academy of Sciences
June 5, 2007
Jean-Claude Béïque, Mays Imad, Ljiljana Mladenovic et al.
Classic hallucinogens such as lysergic acid diethylamide are thought to elicit their psychotropic actions via serotonin receptors of the 5-hydroxytryptamine 2A subtype (5-HT(2A)R). One likely site for these effects is the prefrontal cortex (PFC). Previous studies have shown that activation of 5-HT(2A)Rs in this region results in a robust increase in spontaneous glutamatergic synaptic activity,...
Neuropharmacology
June 2007
Efrain E. Garcia, Randy L Smith, Elaine Sanders‐bush
Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that G(q)-coupled 5-HT(2A) receptors are likely targets for the initiation of events leading to the hallucinogenic behavior elicited by lysergic acid diethylamide (LSD), (+/-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), and related drugs....
Handbook of Contemporary Neuropharmacology
March 2, 2007
María Isabel Colado, Esther O'Shea, Alfred Richard Green
AbstractThe use of the club drugs 3, 4‐methylenedioxymethamphetamine (MDMA, “ecstasy”), gamma‐hydroxybutyrate (GHB), flunitrazepam (Rohypnol), ketamine and LSD is a popular practice among young people especially during all‐night dance parties or “raves“ due to their ability to enhance social experiences and/or alter perception. These substances belong to different classes of drugs: MDMA is an...
Neuron
February 1, 2007
Javier González-Maeso, Noelia V Weisstaub, Mingming Zhou et al.
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR) agonists, yet closely related 2AR agonists such as lisuride lack comparable psychoactive properties. Why only certain 2AR agonists are hallucinogens and which neural circuits mediate their effects are...
Psychopharmacology
January 2007
Daniel Kueh, Lisa E Baker
Relatively few studies have compared the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) and cocaine, and findings from different laboratories are somewhat inconsistent. One possible reason for discrepant results may be the use of different reinforcement schedules during discrimination training. The present study compared fixed ratio (FR) 20 and variable interval...
Meet Me with Your Black Drawers On
December 31, 2006
L. M. Robinson
alive, as did everyday experience. After I came down from the LSD trip, I was deliberately determined to hold onto that freedom—adetermination informed by a structural psychological awareness that had been obtained in the intensity of my earlier psychotherapy experience.My subsequent introduction tomarijuana freed me of physical and sexual awkwardness, turned me onto intimate discourse,...
European Addiction Research
December 18, 2006
Jim Mccambridge, Adam Winstock, Neil Hunt et al.
113 citations
<i>Aims:</i> To describe and assess trends in the use of hallucinogens and other adjunct drugs over a 5-year period. <i>Design:</i> Repeated-measures cross-sectional survey. <i>Setting and Participants:</i> Annual magazine-based survey targeting people who use drugs in dance contexts. <i>Measurements:</i> Lifetime use prevalence (ever used); age of first use; current use prevalence (any use...
The Chemical Educator
December 1, 2006
G. Wayne Craig, George B. Kauffman
Albert Hofmann’s early curiosity about nature’s wonders led him to the field of chemistry. He began his career by identifying the structure of the natural polysaccharide, chitin, and the cardiac-active Scilla glycosides. But it was his synthesis of LSD, an analogue of the ergot alkaloids, that led to a revolution in the pharmaceutical industry, inspiring researchers to understand how the...
Psychopharmacology
December 1, 2006
Kirsten Krebs-Thomson, Erbert M Ruiz, Virginia L Masten et al.
96 citations
The hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is structurally similar to other indoleamine hallucinogens such as LSD. The present study examined the effects of 5-MeO-DMT in rats using the Behavioral Pattern Monitor (BPM), which enables analyses of patterns of locomotor activity and exploration, and the prepulse inhibition of startle (PPI) paradigm. A series of interaction...