Salvinorin A, the main active component of Salvia divinorum, is a potent and selective κ opioid receptor agonist. Synthetic derivatives of this substance may be useful in the development of medicinal treatments for pain, mood disorders, and drug dependence. Such developments require extensive preclinical screening of these compounds. The drug discrimination assay is a valuable method for...
Humana Press eBooksAugust 26, 2011Javed Khan, Thomas J. Kennedy, Donnell R. Christian1 citation
The primary focus is on illicit methamphetamine production; however, synthetic procedures commonly used in the clandestine production of cocaine (HCl and base), fentanyl, gamma -hydroxybutyric acid (GHB), heroin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA, aka ecstasy), methcathinone, phencyclidine (PCP), and N , N -dimethyltryptamine (DMT) are also included. It...
The psychoactive substance 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) with psychedelic qualities is one of many legal so-called Internet drugs. The aim of this qualitative study was to establish an understanding of what characterizes its recreational use. Very little is known about the effects of this substance. Twenty-five anonymous Swedish experience reports (from persons aged 18-30...
Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used traditionally in divination rituals and as a treatment for the "semimagical" disease panzón de borrego. Because of the intense "out-of-body" experiences reported after inhalation of the pyrolized smoke, S. divinorum has been gaining popularity as a recreational hallucinogen, and the United States and several other...
Based on the material available in both the scientific literature and on the web, the present paper provides an updated pharmacological, chemical, toxicological and behavioural overview of Bromo-Dragonfly (1-(8-bromobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane; 'B-fly'). B-Fly is a powerful, long lasting, LSD-like, hallucinogenic drug, which has been associated with a number of acute...
A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryptamine (DMT) use: case report N,N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD).Synthetic production of DMT as well as extraction from several plants of South American flora is possible.DMT...
Here, we integrated manual observations, computerized event‐based scoring and automated video analysis of zebrafish traces to generate three‐dimensional (3D) swim path reconstruction of general behavioral patterns, thereby improving the characterization and interpretation of complex, anxiety‐related adult zebrafish behavior. Drugs known to evoke a high‐anxiety state (caffeine, repeated morphine...
CONTEXT: Media and scientific reports have indicated an increase in recreational use of Salvia divinorum. Epidemiological data are lacking on the trends, prevalence, and correlates of S. divinorum use in large representative samples, as well as the extent of substance use and mental health problems among S. divinorum users. OBJECTIVE: To examine the national trend in prevalence of S. divinorum...
3,4-Methylenedioxymethamphetamine (MDMA; ‘Ecstasy’) shares psychoactive effects with drugs that possess stimulant (e.g. amphetamine, the effects of which are primarily dopaminergic) and hallucinogenic properties (e.g. LSD, which has serotonergic effects) [1]. The majority of MDMA’s distinctive effects as well as its toxicity have been linked to its actions on serotonergic neurotransmission [2]....
There is a growing body of evidence supporting the efficacy of various complementary and alternative medicine approaches in the management of headache disorders. These treatment modalities include nutraceutical, physical and behavioral therapies. Nutraceutical options comprise vitamins and supplements (magnesium, riboflavin, coenzyme Q 10 , and alpha lipoic acid) and herbal preparations...