Peer Review
June 3, 2023
Matheus Antônio Garcia Marson, João Vicente de Paiva Neto, Jayne Zaniratto et al.
A dietilamida do ácido lisérgico (LSD) é uma droga proibida mundialmente, contudo diversos estudos sugerem haver uma variedade de possíveis aplicações terapêuticas e benefícios no tratamento de ansiedade, depressão e abuso de substâncias, além de propriedades nootrópicas. O estudo teve como objetivo verificar aplicações terapêuticas, efeitos relevantes à saúde mental e segurança do LSD como...
Journal of Forensic Sciences
May 1, 2023
Shu-Hua Zhang, Angeline S Y Tang, Reenie S L Chin et al.
7 citations
With the emergence of new psychoactive substances (NPSs) over the years, the substances detected on stamps (also known as blotter papers) have also evolved from the traditional drug-lysergic acid diethylamide (LSD) to the multiple variants of lysergamides such as ALD-52 and 1P-LSD. The analysis of such blotter papers is usually done by solvent extraction followed by identification using gas...
International Journal of Advanced Research
April 30, 2023
Dimple Gupta, Chirag Ambaliya, Aman Ankur et al.
Background:Classical psychedelics are a group of drugs which act as agonists on the serotonin-2A (5-HT2A) receptor. Evidence suggests they may have a uniquely rapid and enduring positive effect on mood. However, marked heterogeneity between methodological designs in this emerging field remains a significant concern. Aims:To determine how differences in the type of psychedelic agent used and the...
Neuropsychopharmacology
April 25, 2023
Peter Bedford, Daniel J. Hauke, Zheng Wang et al.
43 citations
Abstract Psychedelics have emerged as promising candidate treatments for various psychiatric conditions, and given their clinical potential, there is a need to identify biomarkers that underlie their effects. Here, we investigate the neural mechanisms of lysergic acid diethylamide (LSD) using regression dynamic causal modelling (rDCM), a novel technique that assesses whole-brain effective...
Psychotropes
April 21, 2023
Pierre Poloméni
Les adolescents et jeunes adultes participant à des événements musicaux consomment fréquemment des substances psychoactives pour améliorer la qualité des relations et des perceptions. Parmi ces substances, une association de LSD puis de MDMA, prises à une heure d’intervalle, dénommée Candy Flip, connue depuis longtemps, bénéficie d’une bonne réputation. Notre travail explore ces substances en...
Canadian journal of health history = Revue canadienne d'histoire de la sante
April 1, 2023
Andrew Jones
2 citations
In 1962, Ontario's Addiction Research Foundation launched the first double-blind randomized controlled trial of LSD therapy as a treatment for alcoholism. The study, which found that LSD was not effective, was heavily criticized by other therapists working with the drug. These critics argued that the Toronto researchers who carried out the study were biased against LSD and used an...
Cell Reports
March 28, 2023
Vern Lewis, Emma M. Bonniwell, Janelle K. Lanham et al.
129 citations
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-coupled receptors (GPCRs). 2-Br-LSD shows partial agonism at several aminergic GPCRs, including 5-HT2A, and does not induce the head-twitch response (HTR) in...
March 10, 2023
Mika Turkia
4 citations
preprint
In medicine, psychedelics were initially considered as a tool for clinicians to understand psychotic states. Based on the presented case data, a reversal of that concept is proposed: psychedelics could be conceptualized as a tool for people chronically anxious and depressed since early childhood to understand ordinary states of mind (e.g. calmness, hopefulness, relaxation, and joy). The case...
Journal of Psychopharmacology
March 6, 2023
Emma I Kopra, Jason Ferris, Adam Winstock et al.
62 citations
Background: Growing numbers of people are using psychedelics for personal psychotherapy outside clinical settings, but research on such use is scarce. Aims: This study investigated the patterns of use, self-reported outcomes and outcome predictors of psychedelic ‘self-treatment’ of mental health conditions or specific worries/concerns in life. Methods: We use data from the Global Drug Survey...
Psychedelics as Psychiatric Medications
March 1, 2023
Mihai Avram, Felix Müller, Stefan Borgwardt
1 citation
Abstract Lysergic acid diethylamide (LSD) is a potent perception-altering chemical. Since the discovery of its effects almost eighty years ago, LSD has been revered and demonized. Before its ban in the late 1960s, LSD was used to model aspects of psychosis and treat distinct mental disorders such as alcohol addiction and anxiety. The new wave of research on psychedelics as potential treatments...