Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional...
Since reports about CIA-funded LSD studies came out in the 1970s, psychedelic drugs have invoked images of unethical experimentation and "mad scientists" in the public imagination. Even now, as the stigma surrounding psychedelics diminishes in the 21st century, the figure of the "mad scientist" continues to occupy a space in what Ido Hartogsohn calls the "collective set and setting," the larger...
Neurology BulletinDecember 24, 2022Vladimir D. Mendelevich, Veronika N. Konovalova, Galya M. Galiullina et al.
The article describes the case of Daria D., 23 years old, who has been using various drugs (LSD, marijuana, mephedrone) for a number of years and independently abandoned using drags with the transition to the use of microdoses of red fly agaric (Amanita Muskaria). Her mental and addictive status is analyzed. It is concluded that, despite the systematic use of drugs, there are no grounds for...
Abstract Background Lysergic acid diethylamide (LSD) is currently being investigated in psychedelic-assisted therapy. LSD has a long duration of acute action of 8–11 hours. It produces its acute psychedelic effects via stimulation of the serotonin 5-hydroxytryptamine-2A (HT2A) receptor. Administration of the 5-HT2A antagonist ketanserin before LSD almost fully blocks the acute subjective...
Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs. Although the primary psychedelic drug effects are mediated by the 5-HT2A serotonin receptor (HTR2A), the 5-HT2B serotonin receptor (HTR2B) has been used as a model receptor to study the activation mechanisms of psychedelic drugs due to...
Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. We postulate that this increase in entropy may arise in part from a flattening of the brain's control energy landscape, which can be...
L’année 1966 voit l’apparition dans les médias français d’une nouvelle drogue aux effets présentés comme particulièrement délétères. Le LSD serait à l’origine de psychoses prolongées, de suicides, et mènerait la jeunesse américaine à se rebeller contre la société. Or, à cette époque, la substance est encore principalement un médicament et un outil d’étude du cerveau. Des milliers d’articles...
Abstract Background and Aims Hallucinogen use is potentially harmful. Information on whether such use has increased in recent decades is lacking. This study assessed overall and age‐specific time trends in the prevalence of 12‐month hallucinogen use in the US general population. Design Cross‐sectional. Setting Data from the US National Survey on Drug Use and Health, 2002–19. Participants...
A Dietilamida do Ácido Lisérgico (LSD) é uma substância psicoativa, capaz de causar mudanças cognitivas. Ganhou notoriedade nos anos 1960, sendo interligada à cultura hippie. Seu uso foi proibido e considerado nocivo à população, gerando estigmas e preconceitos acerca de substâncias psicoativas no geral. O objetivo foi levantar opiniões a respeito do uso terapêutico do LSD. Trata-se de uma...
While LSD may have had a harsh reputation in decades previous, current research has been investigating its potential as a therapeutic modality. It has been shown that full doses of LSD are capable of providing therapeutic effects however, the concept of "microdosing", or the repeated use of very low doses has become increasingly popular. Yet, the literature does not provide consistent results...