Zusammenfassung Seit den späten 1990er-Jahren erfahren Psychedelika eine Renaissance und ziehen international vermehrt die Aufmerksamkeit auf sich. Es gibt zunehmend wissenschaftliche Studien, die sich mit den Möglichkeiten und Risiken der Psychedelika-assistierten Therapie (PAT) befassen. Seit 2014 werden auf der Grundlage von Ausnahmebewilligungen der Schweizer Gesundheitsbehörde (Bundesamt...
The neurobiological mechanisms underpinning psychiatric disorders such as treatment-resistant major depression, post-traumatic stress disorder, and substance use disorders, remain unknown. Psychedelic compounds, such as psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine, have emerged as potential therapies for these disorders because of their hypothesized ability to induce...
Flicker light stimulation (FLS) is a non-pharmacological method of inducing altered states of consciousness (ASCs), producing hallucination-like phenomena as well as effects extending beyond the visual modality, including emotional effects. Research into the psychological and neural mechanisms of FLS is still in its infancy, but can be informed by research into other methods of inducing ASCs....
Zusammenfassung Erste Studienergebnisse zeigen ein Potenzial von Psychedelika und 3,4-Methylendioxy-N-methylamphetamin (MDMA) für die Behandlung von affektiven Störungen. Im vorliegenden Beitrag wird argumentiert, dass die Ausbildung von Therapeut*innen von entscheidender Bedeutung ist, um diese Substanzen in der Psychedelika-assistierten Therapie (PAT) sicher und wirksam einzusetzen....
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes, such as personality changes. These findings are particularly intriguing, given that a decrease of brain entropy is a robust indicator of loss of consciousness (e.g., from wakefulness to...
Das GesundheitswesenFebruary 1, 2024Ursula Kappl, Bernd Huppertz, Heino Stöver et al.
The aim of this long-term study was to record substance-specific prevalences of illegal use of narcotics despite court-imposed abstinence requirements. Urine assays were obtained by a public health department on the basis of administrative assistance for the probation department of a district court. The individual and valid allocation of these urine samples was ensured using a proven marker...
Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, have been recognized for their ability to enhance neural plasticity through the activation of the serotoninergic and glutamatergic systems....
This narrative review explores the efficacy and tolerability of third-generation antipsychotics (TGAs)-aripiprazole, cariprazine, brexpiprazole, and lurasidone-for the management of substance-induced psychosis (SIP). SIP is a psychiatric condition triggered by substance misuse or withdrawal, characterized by unique features distinct from those of primary psychotic disorders. These distinctive...
Psychosis is defined as a series of symptoms that impair the mind and lead to a kind of loss of reference to reality. Development of psychosis is usually preceded by the appearance of prodromal symptoms. Numerous attempts have been made to find out how psychoactive substances can influence the onset and development of psychotic disorders, but to date there are no studies that show a link...
: Psychedelics are currently being examined once more as potential remedies for untreatable biological illnesses after decades of research problems. They are frequently regarded to be physically safe and do not frequently lead to dependency or addiction. The use of psychedelic substances in the treatment of mental illness and the adoption of the Substance Act of 1970 has classified psychedelic...