Advances in Research
January 30, 2023
Jennings Hernandez
Roughly over 700 million individuals suffer from a mental illness globally. In the United States alone, over 45 million individuals are afflicted with a mental disorder at any given point in their lives. It is because of this that new methods of current therapies should be considered. To date, major depression disorder (MAD), anxiety, and post-traumatic stress disorder (PTSD) are treated with...
Annals of Pharmacotherapy
January 12, 2023
C Michael White, Nissen Weisman, Joseph Dalo
18 citations
Objective: To assess the role of psychedelics in the treatment of anxiety or depression among patients with cancer. Data Sources: PubMed search from inception to March 11, 2022, using the terms anxiety, depression, psychedelics, psilocybin, lysergic acid, methylenedioxymethamphetamine, or ayahuasca. Study Selection and Data Extraction: Studies assessing patients with cancer receiving...
International Journal of Molecular Sciences
January 10, 2023
Andrea Mastinu, Margrate Anyanwu, Marinella Carone et al.
45 citations
The need to identify effective therapies for the treatment of psychiatric disorders is a particularly important issue in modern societies. In addition, difficulties in finding new drugs have led pharmacologists to review and re-evaluate some past molecules, including psychedelics. For several years there has been growing interest among psychotherapists in psilocybin or lysergic acid...
The Brown University Psychopharmacology Update
2023
The effort to identify alternative treatments for anxiety has led to research into the potential of lysergic acid diethylamide (LSD) in reducing anxiety symptoms. Based on results of a placebo‐controlled pilot study showing that two high doses of LSD in patients with a life‐threatening illness resulted in reductions in anxiety for up to 2 months, investigators conducted a Phase 2 study to...
Journal of Psychoactive Drugs
2023
Aviad Hadar, Jonathan David, Nadav Shalit et al.
93 citations
Psychedelics were used in the treatment of psychiatric conditions prior to their prohibition in the late 1960s. In the past three decades, there is a revived research interest in the therapeutic potential of psychedelic drugs with expected FDA approvals for treatment of various conditions. Given the exponential scientific growth of this field, we sought to characterize, analyze, and visualize...
Drug Science, Policy and Law
2023
Antonio Metastasio, Silvio Mignogna, Riccardo Paci et al.
Since its discovery in 1943, LSD has been used by artists, scientists, and intellectuals, amongst others, to stimulate their creative insights. Federico Fellini, one of the most important film directors in the XX century, used LSD when it was still legal under the guidance of his psychoanalyst during a phase of personal and creative crisis. This article proposes a phenomenological analysis of...
Drug Science, Policy and Law
2023
Adriana D’arienzo, Giorgio Samorini
In recent years, the historical record of psychedelic therapy in Europe and the Americas has undergone considerable revision. In this article, we contribute to this re-interpretation by sharing documentation relating to psychedelic therapy carried out in Italy during the period 1927–1966. Our library research has uncovered one hundred publications, documenting at least 60 clinical studies in...
Journal of Psychoactive Drugs
2023
Otto Simonsson, Simon B. Goldberg
37 citations
There are neurophysiological and phenomenological overlaps between psychedelic and meditative states, but there is little evidence on how exposure to psychedelics might be associated with meditation-related variables. We assessed lifetime classic psychedelic use, ego dissolution during one's most intense experience using a classic psychedelic, and exposure to meditation in a representative...
Neuropsychopharmacology
2023
James Glazer, Conor H. Murray, Robin Nusslock et al.
52 citations
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single, high doses of psychedelic drugs have shown promise in treating depressive disorders, perhaps by reversing deficits in reward processing in the brain. In addition, there are anecdotal reports that repeated ingestion of low doses of LSD, or...
Journal of Psychoactive Drugs
2023
Daniel J. Kruger, Nicolas G. Glynos, Christopher W Fields et al.
10 citations
Identifying gaps and strengths in psychedelic-related knowledge is key to developing effective, evidence-based education to inform appropriate use of and harm reduction practices for psychedelics in the naturalistic use landscape. The current study piloted an assessment instrument with questions on legal status, therapeutic potential, and side effects of psychedelics among people reporting...
Psychiatry Research
2023
Flavie Waters
1 citation
Hallucinations are one of the most interesting and least understood of all human experiences. This commentary addresses the ideas which most influenced my thinking in the past 20 years and what I believe to be the most currently promising area of enquiry. Interest in hallucinations reaches far back into antiquity and across cultures. The similarity of hallucinations in mental illness with the...
Journal of Psychopharmacology
2023
Jack E Henningfield, Judy Ashworth, David J Heal et al.
13 citations
Background: Psychedelics are an increasingly active area of research and pharmaceutical development. This includes abuse potential assessment to better understand their pharmacological mechanisms and effects and guide controlled substance regulation. Psychedelics pose challenges to abuse assessments to ensure valid, reliable, and generalizable outcomes and safe study conduct. Findings: Key...
International journal of clinical and health psychology : IJCHP
2023
John R. Kelly, Gerard Clarke, Andrew Harkin et al.
33 citations
Moving towards a systems psychiatry paradigm embraces the inherent complex interactions across all levels from micro to macro and necessitates an integrated approach to treatment. Cortical 5-HT2A receptors are key primary targets for the effects of serotonergic psychedelics. However, the therapeutic mechanisms underlying psychedelic therapy are complex and traverse molecular, cellular, and...
Frontiers in Psychiatry
2023
Deborah Rudin, Alexander Areesanan, Matthias E. Liechti et al.
9 citations
Classic psychedelics have been shown to exert therapeutic potential for the treatment of various psychiatric disorders, neuropsychiatric diseases, and neuronal damage. Besides their psychopharmacological activity, psychedelics have been reported to modulate immune functions. There has thus far been a sparse exploration of the direct immune-modulating effect of psychedelics on human immune cells...
Journal of Psychoactive Drugs
2023
Daniel J. Kruger, Oskar Enghoff, Moss Herberholz et al.
24 citations
There is a surge of interest in psychedelics, including new stakeholders and greater media attention. There is a need to examine the information-seeking behavior of people using psychedelics naturalistically, given the importance of preparation and harm-reduction. We examined sources of information for people using psychedelics naturalistically, and the degree to which they are trusted in a...
Frontiers in Neuroscience
2023
Azat Nasretdinov, Sebastian A Barrientos, Ivani Brys et al.
6 citations
Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional...
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
2023
María T Rivera-García, Silvia L. Cruz
8 citations
Since the dawn of civilization, ancient cultures have utilized hallucinogens from plants and fungi in the context of religious and healing practices. Recently, their use has expanded to other cultures. Hallucinogens are natural or synthetic substances that alter the perception of reality at nontoxic doses, producing intense psychological and physiological effects. The initial research on...
Frontiers in Psychology
2023
Andrew Jones
6 citations
Since reports about CIA-funded LSD studies came out in the 1970s, psychedelic drugs have invoked images of unethical experimentation and "mad scientists" in the public imagination. Even now, as the stigma surrounding psychedelics diminishes in the 21st century, the figure of the "mad scientist" continues to occupy a space in what Ido Hartogsohn calls the "collective set and setting," the larger...
Neurotrauma reports
2023
Stephanie Karzon Abrams, Brenden Samuel Rabinovitch, Rayyan Zafar et al.
5 citations
Psychedelic-assisted therapy (PAT) may treat various mental health conditions. Despite its promising therapeutic signal across mental health outcomes, less attention is paid on its potential to provide therapeutic benefits across complex medical situations within rehabilitation medicine. Persons with spinal cord injury (SCI) have a high prevalence of treatment-resistant mental health...
Expert Review of Neurotherapeutics
2023
Emmanuelle A. D. Schindler, Peter S. Hendricks
5 citations
While the majority of current research and development surrounds depression, demoralization, and substance use disorders, there are numerous reports of psychedelics having beneficial effects in other branches of medicine, including for headache disorders and chronic pain. This perspective reviews conventional forms of treatment for headache and other chronic pain disorders and describes...