Der Nervenarzt
September 1, 2024
Johannes Jungwirth, Francesco Bavato, Boris B. Quednow
6 citations
With the discovery of the antidepressive effects of ketamine and the increasing withdrawal of the pharmaceutical industry from the development of new psychotropic drugs, the psychiatric research into the clinical application of hallucinogens in psychiatry has literally blossomed in the last two decades. Promising results for various treatment approaches with psychedelic agents, such lysergic...
Schizophrenia Bulletin
August 27, 2024
Bianca Bianciardi, Helena Mastek, Michelle Franka et al.
6 citations
N-Methyl-d-aspartate receptor (NMDA-R) hypofunctioning has been hypothesized to be involved in circuit dysfunctions in schizophrenia (ScZ). Yet, it remains to be determined whether the physiological changes observed following NMDA-R antagonist administration are consistent with auditory gamma-band activity in ScZ which is dependent on NMDA-R activity. This systematic review investigated the...
Medicina (Kaunas, Lithuania)
August 5, 2024
Nuray Camgoz Eryilmaz, Mustafa Arslan, Ayşegül Küçük et al.
3 citations
Introduction: We evaluated the effects of repeated ketamine, propofol, and ketamine + propofol administration on cognitive functions and brain tissue of elderly rat models with streptozotocin-induced Alzheimer's disease. Materials and Methods: Thirty elderly male Wistar Albino rats were divided into five groups: control (Group C), Alzheimer's (Group A), Alzheimer's + ketamine (Group AK),...
Cureus
August 1, 2024
Madalena Carvalho, Ana Teresa Guerra, Marta Moniz et al.
Background Painful procedures in the pediatric emergency department often require the use of sedation and analgesia to ensure adequate pain control, a right of children and adolescents. This study aims to describe the procedural sedation and analgesia with intravenous medications performed in a pediatric emergency department. Methods This is a retrospective descriptive study of intravenous...
Aging
July 26, 2024
Karl Berner, Naci Oz, Alaattin Kaya et al.
1 citation
Gain of function disturbances in nutrient sensing are likely the largest component in human age-related disease. Mammalian target of rapamycin complex 1 (mTORC1) activity affects health span and longevity. The drugs ketamine and rapamycin are effective against chronic pain and depression, and both affect mTORC1 activity. Our objective was to measure phosphorylated p70S6K, a marker for mTORC1...
Military Medical Research
July 23, 2024
Hai-Lou Zhang, Yan Sun, Zhang-Jie Wu et al.
24 citations
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...
Open veterinary journal
July 1, 2024
Seyedeh Mina Masoumi, Mohammad Reza Youssefi, Seyed Shapoor Reza Shojaei
2 citations
Chronic toxoplasmosis has been strongly implicated in the development of psychosis and schizophrenia. Additionally, the understanding of schizophrenia has been significantly reshaped by insights into N-methyl-D-aspartate receptor (NMDAR) hypofunction. This study aimed to compare the behavioral, antioxidant, and NMDAR changes in mice subjected to Toxoplasma gondii infection and those treated...
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
June 1, 2024
Sachin Gupta, Deeksha S Tomar
How to cite this article: Gupta A, Tomar DS. Am I Sedated or in Pain? Please Monitor by Brain. Indian J Crit Care Med 2024;28(6):531-532.
BMC Anesthesiology
May 3, 2024
David P Obert, David Killing, Tom Happe et al.
5 citations
The exact mechanisms and the neural circuits involved in anesthesia induced unconsciousness are still not fully understood. To elucidate them valid animal models are necessary. Since the most commonly used species in neuroscience are mice, we established a murine model for commonly used anesthetics/sedatives and evaluated the epidural electroencephalographic (EEG) patterns during slow...
Cell Reports
April 23, 2024
Adeeti Aggarwal, Jennifer Luo, Helen Chung et al.
17 citations
The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this state dependence to identify brain activity associated with internally generated or stimulus-evoked...