Mild cognitive impairment (MCI) is an intermediate stage between normal aging and mild dementia. Patients with MCI and dementia usually experience impairment in cognitive functions such as memory, executive function, and processing speed. They may also develop neuropsychiatric symptoms, such as depression, anxiety, and agitation. While previous studies suggest that mindfulness meditation may...
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...