PLoS One2025Jiuhong You, Zunera Khan, Reena Swaroop et al.
Mild cognitive impairment (MCI) is an intermediate stage between normal aging and mild dementia. Patients with MCI and dementia usually experience impairment in cognitive functions such as memory, executive function, and processing speed. They may also develop neuropsychiatric symptoms, such as depression, anxiety, and agitation. While previous studies suggest that mindfulness meditation may...
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...
This article presents a study protocol for a single-blind randomized controlled trial to test the efficacy and feasibility of mindfulness-based cognitive therapy. A total of 120 un-medicated Chinese obsessive-compulsive disorder patients will be randomized to the mindfulness-based cognitive therapy group, the selective serotonin reuptake inhibitor group or the psycho-education group for 11...