Physiological, pharmacological, and pathological alterations of consciousness provide critical windows into its neural substrates. Given the inherent complexity and multidimensionality of consciousness, defining quantitative, dynamic signatures of neural activity, and translating them into clinically applicable tools remains challenge. This study aimed to build an electroencephalography...
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...