The Journal of ECTApril 28, 2025Selin Balki Tekin, Ayşe Nur İnci Kenar, İhsan Anıl Doğruyol et al.
The present study aims to make a contribution to the extant literature on the sharing of clinical experiences with electroconvulsive therapy (ECT) and the effects of different anesthetic drugs on ECT efficacy. A retrospective analysis of the medical records of patients who were administered ECT from March 2023 to July 2024 was conducted to obtain data on age, gender, psychiatric diagnosis, type...
Children with upper respiratory infections (URIs) have an increased risk of respiratory adverse events when undergoing operative anesthesia and in general populations of children receiving procedural sedation. It is unclear if children with URI undergoing emergency department (ED) sedation share the same increased risk. We aimed to determine if the presence of a URI in children undergoing ED...
'Tusi', also known as 'tusibí' or 'pink cocaine', is a drug concoction which previously emerged in Latin America and Europe and has recently acquired popularity in the United States (US). Consumers are often unaware that Tusi contains a mixture of ketamine and other drugs, and the concoction can be confused with 2C/2C-B (ring-substituted phenethylamines/4-bromo-2,5-dimethoxyphenethylamine) or...
The primate brain is a densely interconnected organ whose function is best understood by recording from the entire structure in parallel, rather than parts of it in sequence. However, available methods either have limited temporal resolution (functional magnetic resonance imaging; fMRI), limited spatial resolution (macroscopic electroencephalography), or a limited field of view (microscopic...
CureusApril 1, 2025Alison Muñoz, Marai Roque, Marco Valladares et al.
This case presents a 33-year-old male with a four-day history of worsening altered mental status and rhabdomyolysis. He experienced delusions, restlessness, and visual hallucinations, exacerbated by prolonged multidrug abuse, including over-the-counter pregabalin (Lyrica) for pain relief and recreational ketamine. Despite an initially incomplete history and unclear etiology, the patient was...
CureusApril 1, 2025Ciara Mimms, Kassandra Sotelo, Abdul Saboor Khaliq1 citation
This systematic review explores the comparative efficacy and functional outcomes of psychedelic-assisted therapies in the management of treatment-resistant depression (TRD). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Scopus, and Web of Science for randomized controlled...
GeroScienceMarch 25, 2025Anna Łysik, Katarzyna Logoń, Aleksandra Szczygieł et al.8 citations
Treatment-resistant depression (TRD) remains a vital challenge in psychiatry, affecting a significant number of patients with major depressive disorder. Current pharmacological approaches often do not provide sufficient therapeutic results, prompting the need for innovative treatments. This review summarizes recent advances in TRD management, including non-pharmacological therapies such as...
JMIR Formative ResearchMarch 11, 2025Mollie R Cummins, Julia Ivanova, Hiral Soni et al.3 citations
In the postpandemic era, telemedicine continues to enable mental health care access for many people, especially persons living in areas with mental health care provider shortages. However, as lawmakers consider long-term telemedicine policy decisions, some question the safety and appropriateness of prescribing via telemedicine, and whether there should be requirements for in-person evaluation,...
Abstract Xylazine, traditionally used as a veterinary sedative, has recently emerged as a new psychoactive substance, being typically ingested in combination with fentanyl derivatives and hence raising significant public health concerns. Despite its increasing prevalence, little is known about its molecular interactions with human neuroreceptors, specifically the serotonin 7 (5‐HT 7 R) and...
Neurobiology of DiseaseMarch 1, 2025Liubov S. Kalinichenko, Iulia Zoicas, Anne-Marie Bienia et al.4 citations
Addiction is a chronic and severe mental disorder with high gender- and sex-specificity. However, the pathogenesis of this disorder is not fully elucidated, and no targeted pharmacotherapy is available. A growing body of evidence points out the potential involvement of the ceramide system in the pathophysiology of addiction. A pathogenic pathway for several mental disorders based on the...