BMC Psychiatry
January 2, 2024
Minna Chang, Mario F Juruena, Allan H. Young
16 citations
Abstract Background Ketamine is a novel and exciting putative antidepressant medication for patients with treatment-resistant depression. A complication commonly seen in frequent and heavy recreational use of ketamine is ulcerative cystitis, which presents with lower urinary tract symptoms (LUTS) and upper renal tract damage and can be seen in over 25% of regular users. Although...
Journal of Psychoactive Drugs
2024
Karim Ait Bentaleb, Mélanie Boisvert, Valérie Tourjman et al.
Ketamine administration leads to a psychotomimetic state when taken in large bolus doses, making it a valid model of psychosis. Therefore, understanding ketamine's effects on brain functioning is particularly relevant. This meta-analysis focused on neuroimaging studies that examined ketamine-induced brain activation at rest and during a task. Included are 10 resting-state studies and 23...
Neuropsychopharmacology
January 2024
Jenessa N Johnston, Bashkim Kadriu, Christoph Kraus et al.
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the development of neuropsychiatric therapeutics, one characterized by an antidepressant response that occurred within hours or days rather than weeks or months. Considerable clinical research supports the use of-or further research with-subanesthetic-dose ketamine and its (S)-enantiomer esketamine in multiple...
Proceedings of the Second Southern Science Conference. Book B
2024
N. González, P. Ramirez, Esther Berenice Vargas Hunger et al.
Ketamine-induced psychotic episodes with hallucinations and sensory dissociation when abused. In rats, prolonged intraperitoneal ketamine (K) administration increases locomotor activity. Neuroactive steroids modulate responses to such drugs. This study aimed to investigate ketamine-induced neuroadaptive effects and neuromodulatory phenomena from Estradiol (E2) and Progesterone (P4) in female...
Telangana Journal of Psychiatry
2024
Pallavi Preetinanda, Srikrishna Nukala, Abhilash Garapati et al.
Treatment-resistant depression (TRD) is one of the most debilitating conditions that does not respond to conventional pharmacotherapy. Ketamine is a recently used effective treatment option in depressive disorders with a novel mechanism of action. Still, studies estimating the improvement of depressive symptoms in TRD with multiple doses of ketamine are limited. Hence, we report 5 TRD cases...
Journal of Psychiatry and Mental Health
2024
CJ Bonnett, J Bonder, R Jain et al.
Since 2020 there has been an expansion in the number of studies highlighting the positive effect that Ketamine for Non-Anesthetic Indications (KNAI) can have on patients suffering with mental health disorders. Medicaid programs cover a large community of patients that face significant health disparities and suffer more frequently from mental health conditions. Many of these conditions are...
International Journal of Pharmacy and Pharmaceutical Research
2024
Ankita Dudhal, Shrenik Dungarwal, Vinod M. Thakare
Ketamine is known for its dissociative anaesthetic properties and hallucinogenic effects.It can distort perceptions of sight and sound, leading to feelings of disconnection from one's surroundings.Commonly administered as an injectable, ketamine is a short-acting anaesthetic used for inducing sedation, immobility, pain relief, and amnesia in both humans and animals.However, it is often misused...
Medical Research Archives
2024
Daniel Kleinloog
Ketamine is a dissociative anesthetic with unique pharmacological and psychological properties. Its antidepressant effects are mediated through the glutamatergic system and subsequent neuroplasticity and can be amplified when combined with psychotherapy. The ketamine-induced dissociative state should not be seen as an unwanted side-effect, but as a unique opportunity for psychotherapeutic...
Journal of Psychoactive Drugs
2024
Reid Robison, Madeline Brendle, Claire Moore et al.
This study reports on 10 frontline healthcare workers, employed during the COVID-19 pandemic and experiencing symptoms of burnout and PTSD, treated with group ketamine-assisted psychotherapy (KAP) in a private outpatient clinic setting. Participants attended 6 sessions once weekly. These included 1 preparation session, 3 ketamine sessions (2 sublingual, 1 intramuscular), 2 integration sessions....
Journal of Affective Disorders
2024
Liliana Patarroyo-Rodriguez, Vanessa M. Pazdernik, Jennifer L. Vande Voort et al.
12 citations
BACKGROUND Sleep disturbances are highly prevalent in depressive episodes and are linked to higher mood severity and suicidal behaviors. Slow wave sleep (SWS) and REM sleep are compromised in depression. Current evidence suggests that rapid antidepressant effects of intravenous (IV) ketamine in patients with treatment-resistant depression (TRD) is mediated by its effects on SWS and REM sleep....