Ketamine is a dissociative anesthetic with unique pharmacological and psychological properties. Its antidepressant effects are mediated through the glutamatergic system and subsequent neuroplasticity and can be amplified when combined with psychotherapy. The ketamine-induced dissociative state should not be seen as an unwanted side-effect, but as a unique opportunity for psychotherapeutic...
This analysis examines the neuronal foundation of drug-induced psychomimetic symptoms by relating the severity of these symptoms to changes in functional connectivity for a range of different psychoactive compounds with varying degrees of psychomimetic effects. The repeated measures design included 323 resting-state functional magnetic resonance imaging time series and measures of subjective...
The effects of drugs are not only determined by their pharmacological action, but also by user characteristics. This analysis explored the influence of personality on the differences in subjective effects in response to a standardized pharmacological challenge with the cannabinoid CB1/CB2 partial agonist Δ9-tetrahydrocannabinol (THC). To express the sensitivity to THC,...
The subjective effects of cannabis and its main psychoactive component Δ(9) -tetrahydrocannabinol (THC) have played an important part in determining the therapeutic potential of cannabinoid agonists and antagonists. The effects mainly consist of feeling high, changes in perception, feelings of relaxation and occasionally dysphoric reactions. These effects are captured by two of the most...