Overview on Drug of Abuse: Ketamine
Ankita Dudhal, Shrenik Dungarwal, Vinod M. Thakare
International Journal of Pharmacy and Pharmaceutical Research 2024 DOI: 10.25166/ijppr.2024.30.10.03 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Esketamine Ketamine |
| Key findings | Reviews ketamine's pharmacological properties, including its dissociative anaesthetic effects, FDA approval for treatment-resistant depression, and its potential for misuse and use in sexual assault. |
Abstract
Ketamine is known for its dissociative anaesthetic properties and hallucinogenic effects.It can distort perceptions of sight and sound, leading to feelings of disconnection from one's surroundings.Commonly administered as an injectable, ketamine is a short-acting anaesthetic used for inducing sedation, immobility, pain relief, and amnesia in both humans and animals.However, it is often misused for its dissociative and hallucinogenic effects, and has unfortunately been used in instances of sexual assault.The term "dissociative anaesthetic" describes its ability to create a sense of detachment from pain and the environment Ketamine, a less toxic alternative to phencyclidine, was developed decades ago.It is now approved by the FDA for treatment-resistant depression in adults.Esketamine, a derivative of ketamine, is also available as a liquid or off-white powder, known as Special K, K, super K, or Vitamin K.In this review paper we are mainly going to review origin, chemical and physical properties, mechanism of action, side effects of Ketamine.Also we ae going to review 'Drug Abuse'.
Comparable studies
Other narrative reviews on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms | 2018 | Review | |
| Mechanisms of Ketamine Action as an Antidepressant | 2018 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) | 2013 | Review | |
| A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | 2017 | Review and consensus statement |