NEUROMODULATORY EFFECTS OF ESTRADIOL AND PROGESTERONE ON KETAMINE'S ACTION IN FEMALE RAT BRAIN
N. González, P. Ramirez, Esther Berenice Vargas Hunger, Ricardo J. Cabrera
Proceedings of the Second Southern Science Conference. Book B 2024 DOI: 10.48141/sscon_48_2024.pdf (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled animal experiment (preclinical study) Peer reviewed |
|---|---|
| Population | Ovariectomized female rats |
| Interventions | Ketamine Estradiol (E2) Progesterone (P4) |
| Measures | Open field behavioral test (locomotor activity), EthoWatcher software |
| Topics | Esketamine Ketamine |
| Key findings | Repeated ketamine administration increased locomotor activity in ovariectomized female rats, and estradiol and progesterone supplementation further raised locomotor activity in sensitized animals. The authors argue that these hormones enhance ketamine-induced potentiation via genomic and non-genomic interactions, producing what they call positive neuroadaptive plasticity. |
Abstract
Ketamine-induced psychotic episodes with hallucinations and sensory dissociation when abused. In rats, prolonged intraperitoneal ketamine (K) administration increases locomotor activity. Neuroactive steroids modulate responses to such drugs. This study aimed to investigate ketamine-induced neuroadaptive effects and neuromodulatory phenomena from Estradiol (E2) and Progesterone (P4) in female rats. Female rat ovariectomies (OVX) were performed, followed by open field behavioral tests to assess locomotor activity (LA), which were analyzed using the EthoWatcher software. Significant LA increases were observed in control EP and K groups vs. C. E2 and P4 further raised LA in sensitized OVX animals. The results demonstrate that E2 and P4 supplementation enhances potentiation, indicating genomic and non-genomic interactions, leading to positive neuroadaptive plasticity with K.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |