Over two dozen Indian medicinal plants belonging to the families Leguminosae, Gramineae, and Malpighiaceae have been screened for potential psychodelic substances. The evaluation of only the indole bearing plants is reported here. Localization of about forty indole alkaloids, representing four broad structural types, viz., indole–3–alkylamines, carboxylated tryptamines, β–carbolines, and...
Most people associate drug abuse with the use of a few “standard” drugs only, but in fact new drugs are constantly being introduced. This paper presents information on drugs whose use by drug abusers is not well known to practitioners. The drugs and drug sources discussed are: the hallucinogenic mushroom (Psilocybe cubensis), Romilar, DMT, “STP”, Mandrax, “mellow yellow”, lighter fluid, amyl...
We determined the types and amounts of alkaloids found in four reed canarygrass ( Phalaris arundinacea L.) genotypes that differed in palatability. The palatability differences had been demonstrated previously in cafeteria grazing trials with lambs. The following alkaloids were identified in reed canarygrass by combinations of gas‐liquid chromatography, thin‐layer chromatography, and mass...
Four indole–3–alkylamines, viz., N,N–dimethyltryptamine, its N b –oxide, bufo–tenine, and 5–methoxy–N,N–dimethyltryptamine along with two uncharacterized 5–oxy–indole–3–alkylamines and a β–carboline were isolated from the various parts, except the trichomes of pods, of Mucuna pruriens DC. The trichomes of pods afforded only serotonin. Besides these, choline was found in all parts of the plant....
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The tests are recommended in conjunction with other analytical techniques if applied for the forensic identification of hallucingens.
1. DeShon, Rinkel & Solomon, Mental Changes Experimentally Produced by LSD, 26 PSYCHIAT.Q. 33 (1952).2. Stoll & Hofmann, Partialsynthese von AlkalZiden vom Typus des Ergobasins, 26 HELvET.CHim.AcmA.944 (1943).See Laughlin, LSD-25 and the Other Hallucinogens: A Pe-Reform Proposal, 36 GEo.WAsH.L. REv. 23, 27 n.23 (1967), for a brief discussion of the history and sources of the other...
Abstract Various ultraviolet, infrared, and TLC procedures are described for the separation and identification of hallucinogenic drugs. Specific methods for LSD, DMT, and psilocybin are also presented, along with general background information for the hallucinogenic drugs.
SIMPLE INDOLE derivatives like the alkylated tryptamines, N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET), produce psychotogenic-like symptoms similar to lysergic acid diethyemide (LSD) and mescaline.1-4 One of the important metabolic pathways of DET has been shown to be by 6-hydroxylation.5The known metabolic pathways of DET are summarized in Fig 1. Other investigators have...
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
In the last 2 decades, there is a renaissance in the scientific investigation of the therapeutic potential of psychedelic compounds. It is studied for the treatment of many psychiatric disorders, including posttraumatic stress disorder. The treatment is always done in the setting of psychedelic-assisted psychotherapy. A little is known about the potential effects, outside of the setting of...