Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds
Science August 4, 1961 DOI: 10.1126/science.134.3475.343 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbit lung |
| Topics | Mescaline Psilocybin Serotonin |
| Keywords | Psychotomimetic Tryptamine Phenethylamine Tyramine Enzyme Dopamine Biochemistry Hallucinogen Pharmacology Stereochemistry |
| Citations | 183 |
| Key findings | An enzyme localized in rabbit lung N-methylates serotonin and tryptamine to produce psychotomimetic metabolites and also acts on several phenylethylamine derivatives. |
Abstract
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
-
State of the evidence: Mescaline Supports
An enzyme localized in rabbit lung N-methylates serotonin and tryptamine to psychotomimetic metabolites and also acts on phenylethylamine derivatives including mescaline.
Synthesized
Comparable studies
Other experimental studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE Schizophrenic patients | 1957 | Experimental study | |
| Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity Isolated basilar and middle cerebral arteries | 1981 | Experimental study | |
| Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148 | 1959 | Experimental study | |
| Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions. Uterus of spayed rat | 1956 | Experimental study | |
| Extraordinary Experiences during Cross-Modal Perception Human participants | 1976 | Experimental study | n = 9 |
Citations in the library
Cited by 44
- The Hallucinogen N,N -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator Science February 13, 2009
- Enzymatic Synthesis of Psilocybin Angewandte Chemie International Edition August 1, 2017
- Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS One 2014
- N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Frontiers in Neuroscience August 6, 2018
- Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities Frontiers in Immunology July 14, 2015
and 39 more in the library