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September 4, 2018 Marc Wittmann
What altered states of consciousness—the dissolution of feelings of time and self—can tell us about the mystery of consciousness. During extraordinary moments of consciousness—shock, meditative states and sudden mystical revelations, out-of-body experiences, or drug intoxication—our senses of time and self are altered; we may even feel time and self dissolving. These experiences have long been...
Aging & Mental Health September 2018 Lotte Berk, Rafke Hotterbeekx, Jim van Os et al.
In a rapidly aging world population, an increasingly large group faces age-related decline in cognitive functioning. Cognitive complaints of older adults are often related to worries and concerns associated with age-related functional decline. Mindfulness-Based Stress Reduction (MBSR) can successfully target stress, worry and ruminative thinking, but the applicability of this method in...
The Journal of AMD September 1, 2018 Valentina Turra
The management of diabetes as a chronic disease requires constant care, adjustments of therapy and strong engagement of both the person with diabetes and the whole care team.However despite the educational and pedagogical efforts, the patient's adherence to the continuity of care, learning and conscious self-management of the illness, may remain open critical issues.The psycho-emotional...
Shenakht Journal of Psychology and Psychiatry September 1, 2018 Maryam Ghorbani, Maryam Najafi, Sedigheh Rezaei Dehnavi 2 citations
Introduction:The neuroticism is persons tend to experience the negative emotions as anxiety, depression and anger and considered as a risk factor for a wide spectrum from affective disorders.Aim: The purpose of this study wase to determine the effectiveness of mindfulness based stress reduction on executive function, cognitive flexibility in women with neuroticism. Method:The method this...
Journal of Labelled Compounds and Radiopharmaceuticals September 2018 Lu Chen, Yong Gong, Rhys Salter
Ketamine is a well-known general anesthetic that inhibits cerebral NMDA receptors. Norketamine is a major circulating metabolite of this drug. A nasal spray formulation of esketamine, the S enantiomer of ketamine, is under development for the management of treatment-resistant depression. To assess the pharmacokinetic properties, C-14 labeled ketamine and norketamine were prepared separately...
Neurochemistry International September 2018 Mauren K Tavares, Suellen Dos Reis, Nicolle Platt et al.
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the most robust neurobiological findings in the pathophysiology of major depressive disorder (MDD) over the last 40 years. The persistent increase in glucocorticoids levels induces morphological and anatomical changes in the brain, especially in the hippocampus. Ketamine represents a major advance for the treatment of MDD,...
Pharmacology, Biochemistry, and Behavior September 2018 Zheng Tian, Chao Dong, Atsuhiro Fujita et al.
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has robust antidepressant effects in depressed patients although it has detrimental side effects such as psychotomimetic and dissociative symptoms. (R,S)-Ketamine is known to cause the expression of heat shock protein HSP-70 (a marker for neuronal injury) in the retrosplenial cortex of rat brain, suggesting that the...
BJPsych Open September 1, 2018 Jolien K E Veraart, Sanne Y Smith-Apeldoorn, Hayley Trueman et al. 9 citations
BACKGROUND: Off-label ketamine treatment has shown acute antidepressant effects that offer hope for patients with therapy-resistant depression. However, its potential for integration into treatment algorithms is controversial, not least because the evidence base for maintenance treatment with repeated ketamine administration is currently weak. Ketamine is also a drug of misuse, which has raised...
Neuropsychopharmacology September 2018 Chadi G. Abdallah, Henk M De Feyter, Lynnette A. Averill et al.
The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (13C MRS) methods have shown ketamine and other N-methyl-D-aspartate (NMDA) receptor antagonists to...
Der Nervenarzt September 1, 2018 K Meister, S Becker
The demand for complementary clinically efficacious, safe, patient acceptable, and cost-effective forms of treatment for mental illness is growing. Yoga has beneficial effects on somatic and mental health factors; therefore, yoga has preventive and therapeutic capabilities to improve mental dysfunction. In this overview of the current literature, the evidence of the effects of yoga on selected...