RCMOS - Revista Científica Multidisciplinar O Saber
March 22, 2022
Fabricio Chaves de Melo Castelo Branco
This article addresses treatment-resistant depression (TRD) as one of the main contemporary challenges in psychiatry, highlighting the need for innovative and safe therapeutic approaches. The study aims to analyze the multidisciplinary role of the anesthesiologist in the administration of subanesthetic doses of ketamine, a drug that has demonstrated rapid and clinically relevant antidepressant...
Neuropsychopharmacology
March 17, 2022
Danilo de Gregorio, Antonio Inserra, Justine P. Enns et al.
89 citations
Lysergic acid diethylamide (LSD) is a serotonergic psychedelic compound receiving increasing interest due to putative anxiolytic and antidepressant properties. However, the potential neurobiological mechanisms mediating these effects remain elusive. Employing in vivo electrophysiology, microionthophoresis, behavioral paradigms and morphology assays, we assessed the impact of acute and chronic...
Indian Journal of Private Psychiatry
March 16, 2022
M R Nagendra Gowda
Psychedelics are classed as a schedule I substance under the Controlled Substances Act of 1970 because of the potential for mind-changing effects. In vulnerable people, unsupervised use has the potential to lead to suicide. However, the management of end-of-life anxiety, severe resistant depression, resistant obsessive-compulsive disorder, and substance abuse is met with a high failure rate....
Research, Society and Development
March 16, 2022
Alexandre Machado de Moura, Marcela Barboza de Melo Aragão, Dário César de Oliveira Conceição et al.
2 citations
Objetivo: Investigar evidências terapêuticas da Ayahuasca, que é uma bebida psicoativa obtida da decocção de duas plantas de origem amazônica: Banisteriospsis caapi (cipó Mariri) e Psychotria viridis (Chacrona), comprovadas em estudos clínicos controlados em pacientes com transtornos psiquiátricos. Metodologia: Trata-se de uma revisão integrativa da literatura focada em ensaios clínicos...
Drug and Alcohol Dependence Reports
March 16, 2022
Elena Argento, Shira Goldenberg, Kathleen Deering et al.
6 citations
Background: Psychedelic-assisted therapies are receiving mounting attention for their therapeutic potential. However, little is known about interest among women who experience elevated risk of mental health and substance use disorders. This study examined interest in receiving psychedelic-assisted therapy and socio-structural factors associated with interest among marginalized women. Methods:...
Brain Sciences
March 15, 2022
Laura Prieto-Arenas, Ignacio Díaz, María Carmen Arenas
26 citations
Gender differences in psychiatric disorders and drug use are well known. Cannabis is the most widely used illegal drug among young people. In recent years, its use has been related to the development of psychiatric pathologies; however, few studies have incorporated the gender perspective as of yet. The present work analyses the literature to determine the existence of gender differences in the...
BMC Psychiatry
March 15, 2022
Lingsha Ju, Jiao-Jiao Yang, Tingting Zhu et al.
Background Preclinical studies have indicated that the ketamine metabolite ( 2R,6R )-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects and molecular mechanisms remain unclear. In this work, we examined the involvement of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB)...
Frontiers in Neuroscience
March 15, 2022
Maria Bălăeţ
28 citations
Psychedelic compounds hold the promise of changing the face of neuroscience and psychiatry as we know it. There have been numerous proposals to use them to treat a range of neuropsychiatric conditions such as depression, anxiety, addiction and PTSD; and trials to date have delivered positive results in favor of the novel therapeutics. Further to the medical use, the wider healthy population is...
Psychotherapy and Psychosomatics
March 14, 2022
Felipe A Jain, Sergey V. Chernyak, Lisa D Nickerson et al.
Introduction: Family caregivers of patients with dementia suffer a high burden of depression and reduced positive emotions. Mentalizing imagery therapy (MIT) provides mindfulness and guided imagery skills training to improve balanced mentalizing and emotion regulation. Objective: Our aims were to test the hypotheses that MIT for family caregivers would reduce depression symptoms and improve...
Frontiers in Psychiatry
March 14, 2022
Edmund C. Neuhaus, George M. Slavich
14 citations
One of the most recent and potentially promising advancements in the health sciences has involved the attempted use of psychedelics for treating mental and behavioral health problems, such as anxiety, depression, posttraumatic stress disorder, and addiction. Despite surging scientific and public interest in this work, however, we presently have no standard of care or consensus regarding how...