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Tingting Zhu

4 papers in the library · 46 citations · publishing 2024-2025

Papers

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Subdiaphragmatic vagotomy reduces hypothalamic oxytocin expression and blood levels after oral MDMA administration in male rats.

Progress in neuro-psychopharmacology & biological psychiatry March 20, 2025 Yong Yue, Xiayun Wan, Guilin Liu et al. 4 citations

3,4-Methylenedioxymethamphetamine (MDMA) is a widely recognized entactogen frequently used recreationally. It is known for its interaction with the serotonin and oxytocin systems, which underlie its entactogenic effects in humans. Recently, we demonstrated that the gut-brain axis, mediated by the subdiaphragmatic vagus nerve, contributes to MDMA-induced resilience enhancement in rodents. This...

DOI: 10.1016/j.pnpbp.2025.111260 (opens in new tab) Full text (opens in new tab) Gut-brain axis Oxytocin Paraventricular nucleus Supraoptic nucleus +4

Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice.

European Journal of Pharmacology March 15, 2025 Mingming Zhao, Akifumi Eguchi, Rumi Murayama et al. 6 citations

3,4-Methylenedioxymethamphetamine (MDMA), commonly known as a recreational drug, may also offer therapeutic benefits for mental health. Population-based studies suggest that MDMA users have a lower risk of demyelinating diseases, such as depression. Given the role of the gut microbiota in mediating MDMA's effects, we hypothesized that MDMA might confer mental health benefits via the gut-brain...

DOI: 10.1016/j.ejphar.2025.177345 (opens in new tab) Full text (opens in new tab) MDMA Demyelination Gut microbiota Metabolites +4

Effects of 3,4-methylenedioxymethamphetamine on the gut microbiota and metabolites in the small intestine, cecum, and colon of male rats.

Progress in neuro-psychopharmacology & biological psychiatry January 10, 2025 Dan Xu, Akifumi Eguchi, Rumi Murayama et al. 4 citations

3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) is a widely abused recreational drug that has also gained interest for potential clinical applications in mental health. With the growing recognition of gut microbiota's role in mental health, this study examined whether repeated oral MDMA administration could affect gut microbiota in the small intestine, cecum, and colon of male rats. Repeated...

DOI: 10.1016/j.pnpbp.2024.111223 (opens in new tab) Full text (opens in new tab) Molly Entactogen Gastrointestinal tract Gut microbiota +6

Ketamine and its two enantiomers in anesthesiology and psychiatry: A historical review and future directions

Journal of Anesthesia and Translational Medicine July 11, 2024 Kenji Hashimoto, Mingming Zhao, Tingting Zhu et al. 32 citations

Ketamine, a dissociative anesthetic, is widely utilized in both human and veterinary anesthesia. Its (S)-enantiomer, esketamine, is similarly employed for anesthesia and analgesia. The anesthetic effects of both ketamine and esketamine arise from their antagonism of the N-methyl-D-aspartate receptor (NMDAR). In field of psychiatry, the rapid-acting antidepressant properties of ketamine for...

DOI: 10.1016/j.jatmed.2024.07.001 (opens in new tab) Ketamine Treatment-resistant depression Major depressive disorder Anxiety +10