Biology of Sex Differences
October 24, 2023
Sandra Ledesma-Corvi, Jordi Jornet-Plaza, M. García-Fuster
Ketamine is a novel fast-acting antidepressant recently approved for treatment-resistant depression. Since preclinical studies showed sex differences in its efficacy, probably driven by sex hormones (estrogens and testosterone), we evaluated the antidepressant-like effects of ketamine in male and female rats when the biosynthesis of estrogens was inhibited. To do so, we utilized letrozole, an...
Pharmacological Reports
October 24, 2023
Agnieszka Wsół
56 citations
Abstract Psychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseases was known before their prohibition. An increasing number of recent studies, due to the indisputable resurgence of serotonergic hallucinogens, have shown their efficacy in alleviating depression, anxiety, substance abuse therapies, and...
International Journal of Education and Literacy Studies
October 20, 2023
Ezgi Özeke-Kocabaş, Bengisu Koyuncu
1 citation
This preliminary study aims to address situations such as high anxiety, stress, inability to focus, and physical burnout experienced by students in the exams made during the transition to a higher education process in the educational system. It also aims to contribute to the development of students’ academic and social-emotional skills, in other words emotional literacy through mindfulness...
The Plant Journal
October 20, 2023
Gwendolyn K. Kirschner
2 citations
The small, globular cactus peyote (Lophophora williamsii) is known for its ability to produce mescaline, a phenethylamine protoalkaloid (Figure 1). Consuming the mescaline-containing dried tops or “buttons” of peyote has a psychedelic effect that has been used in religious ceremonies by Indigenous communities for over 5800 years (Cassels & Sáez-Briones, 2018). Nowadays, psychedelic drugs are...
Canadian Liver Journal
October 19, 2023
Makayla Watt, Ashley Hyde, John C. Spence et al.
9 citations
Background: Persons with primary biliary cholangitis (PBC) experience significantly higher rates of mental distress and impaired health related quality of life (HrQoL) than the general population. Given limited evidence, but a high need, our primary aim was to assess feasibility and acceptability of a 12-week, online, mind–body wellness program in people with PBC. Methods: This was a...
Mindfulness
October 19, 2023
María Fernanda López-Ramón, Verónica Moreno Campos, Yurena Alonso-Esteban et al.
10 citations
Abstract Objectives The COVID-19 pandemic has caused high mortality rates worldwide, as well as consequent psychological and physical stress. The present study aimed to review the main existing scientific research studies conducted since the onset of the COVID-19 that have used mindfulness-based interventions (MBIs) as tools for emotional regulation, aiming to improve individuals’ ability to...
ACS Medicinal Chemistry Letters
October 19, 2023
Robert B. Kargbo
2 citations
Addressing the significant challenges of treating depression, anxiety, and substance abuse, this Patent Highlight explores the development of innovative small-molecule heterocyclic compounds as Gq-biased agonists of the 5-HT2A receptor. Unlike traditional treatments, these compounds selectively activate 5-HT2A-mediated Gq signaling, excluding related receptors like 5-HT2B and 5-HT2C. This...
Nature Communications
October 19, 2023
Laura M Hack, Xue Zhang, Boris D. Heifets et al.
20 citations
Ketamine commonly and rapidly induces dissociative and other altered states of consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these experiences remain unknown. We used functional neuroimaging to engage key regions of the brain’s affective circuits during acute ketamine-induced ASCs within a randomized, multi-modal, placebo-controlled design examining placebo,...
Psychopharmacology
October 19, 2023
Arya Rahbarnia, Zhaoxia Li, Paul J Fletcher
9 citations
Neuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by the serotonin (5-HT) neurotransmitter system. The 5-HT2A agonist and hallucinogen psilocybin (PSI) is a promising treatment for disorders characterized by attention changes. However, few studies have investigated PSI's direct effect on attention. Using the rodent continuous...
Psychiatry International
October 18, 2023
Eleni Mitsea, Athanasios Drigas, Charalabos A. Skianis
25 citations
International psychiatry is facing major challenges due to the rapid increase in mental health issues. The forthcoming mental health crisis has opened the debate about the need to broaden the therapeutic horizons with the implementation of digitally assisted mindfulness practices within psychotherapeutic interventions. Mindfulness training is developing into a promising intervention for a...