Scientific Reports
August 29, 2025
Abbie L Little, Malcolm Boyle
Paramedics worldwide have a higher prevalence of PTSD, anxiety, and depression than the general population. Paramedicine students predominately enter the profession without preventative techniques to manage stress, depression and fatigue. The objective of this study was to examine the effect of Transcendental Meditation (TM) on the well-being and resilience of paramedicine students. A pilot...
BMC Pharmacology and Toxicology
August 29, 2025
Bin Deng, Zhiwen Fu, Linjie Li et al.
3 citations
AIMS: This study aims to investigate the safety profile of Esketamine, with a particular focus on comparing adverse events (AEs) between adults (< 65 years) and older adults (≥ 65 years) using data from the FDA Adverse Event Reporting System (FAERS). METHODS: We conducted a comprehensive analysis of FAERS data from 2019 to 2024, identifying 6,452 Esketamine-related AE reports. After removing...
August 29, 2025
Romesha Uduwawela
<p><strong>Psilocybin, the psychoactive compound found in certain mushrooms, has gained increasing attention for its potential therapeutic applications in mental health treatment. While clinical research highlights its efficacy in alleviating mental disorders, such as depression, anxiety, PTSD, and substance use disorders, much remains to be known about the role of acute doses of psilocybin...
Journal of Psychopharmacology
August 29, 2025
Niall M. Mcgowan, James Rucker, Rachel Yehuda et al.
10 citations
Background: Post-traumatic stress disorder (PTSD) is a debilitating condition for which there are few efficacious treatments. Psilocybin is being studied for use in treatment-resistant depression but has not yet been investigated in PTSD. Aims: The trial’s primary outcome was to investigate the safety and tolerability of single-dose psilocybin in participants with PTSD. Methods: This was a...
medRxiv
August 28, 2025
Franziska Stadler, Johan Saelens, Ioline D. Henter et al.
preprint
This international online study (N=759) examined the acute, subacute, and long-term effects of psychedelic drug use on cognitive performance and mental health. Participants completed cognitive tasks assessing working memory, selective attention, and visual/spatial perception, as well as questionnaires assessing mental health outcomes and quality of life. Based on self-reported substance use,...
Advanced International Journal for Research
August 27, 2025
Seema Rath
Mental health has emerged as a global concern in the 21st century, marked by rising cases of anxiety, depression, and stress-related disorders. Amidst this psychological crisis, the ancient Indian practice of meditation has garnered renewed attention. Rooted in profound philosophical systems like Ved?nta, S??khya, Yoga, and Buddhism, meditation is not merely a therapeutic tool but a...
International Journal of Basic and Applied Sciences
August 27, 2025
Pallabi Mukherjee -, Ankita Sharma, Vinita Ramchandani et al.
The research paper uses bibliometric analysis to analyze worldwide trends of yoga and meditation research between the years 2010 and 2025. With citation and co-citation analysis, the paper establishes top authors, nations, and repeating patterns. Results reveal consistent growth in publications, highest between 2020–2022, spurred by post-COVID health consciousness and India's 2020 National...
NeuroSci
August 27, 2025
Alexander Thomas, R Andrew Chambers
4 citations
Interest in ketamine as a novel treatment for substance use disorders (SUDs) has been increasing due to its N-methyl-D-aspartate (NMDA) glutamate receptor antagonism and mounting evidence that glutamate neurotransmission is involved in the pathogenesis of both depression and addictions. This narrative review provides an outline of clinical evidence reported in the literature from the 1970s to...
Pharmaceutical Science
August 27, 2025
Guilllermo Castaño-perez, Sara Isabel Castaño-ocampo
The resurgence of research on the use of psychedelic substances for the treatment of mental disorders and addictions has generated significant interest in the scientific and clinical communities. This chapter examines the current evidence on the efficacy, safety, and limitations of psychedelics in the treatment of these conditions. Studies investigating the use of psychedelics as monotherapy...
Acta neurológica colombiana
August 26, 2025
Gianfranco Faccini-Durán
Introducción: la psilocibina, un alcaloide triptamínico presente en hongos genero psilocybe, actúa uniéndose a receptores serotoninérgicos de tipo 2A (5HT2A), activando respuestas metabotrópicas y resultando en procesos de neuroplasticidad. Se integran diversas metodologías de abordaje científico, incluyendo estudios pre clínicos y clínicos, sobre con los efectos neurofisiológicos, y el...