Research published in Journal of Neurophysiology

An EEG-Based Evaluation of Antidepressant Effects of Ketamine Enantiomers and Metabolites in Monkeys.

Journal of Neurophysiology August 26, 2026

An EEG-Based Evaluation of Antidepressant Effects of Ketamine Enantiomers and Metabolites in Monkeys.

DOI: 10.1152/jn.00204.2026

Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques.

Journal of Neurophysiology April 1, 2026 Yoshihiro Iwamura, Kantaro Nishigori, Masataka Yamaguchi et al.

(R,S)-Ketamine, a dissociative anesthetic, has shown rapid and sustained antidepressant effects at lower doses than those required for anesthetic effects in patients with treatment-resistant depression. However, its use is limited because it causes side effects, including psychotomimetic symptoms and dependence. The enantiomer (R)-ketamine was reported to promote antidepressant-like effects in...

DOI: 10.1152/jn.00203.2025 Full text Electroencephalography Ketamine enantiomers Ketamine metabolites Rhesus monkey

On consciousness in animals and in artificial intelligence.

Journal of Neurophysiology April 1, 2026 Yuri I Arshavsky

In recent years, numerous publications have emerged claiming that animals possess consciousness. Moreover, neurophysiological literature has discussed the possible existence of consciousness in artificial intelligence (AI). Both ideas stem from analyses of the behavior of animals and AI systems. Here, I argue that it is impossible to draw conclusions about animal consciousness based solely on...

DOI: 10.1152/jn.00019.2026 Full text Artificial intelligence Consciousness Different sensory perception Memory

Serotonergic modulation of cortical gamma synchronization: right-lateralized psilocin effects on 40 Hz auditory steady-state responses in rats.

Journal of Neurophysiology April 1, 2026 Inga Griškova-bulanova, Čestmír Vejmola, Tomáš Páleníček

Auditory steady-state responses (ASSRs), particularly at 40 Hz, are promising biomarkers for psychiatric disorders involving dysregulated neural synchronization. Although most ASSR studies have focused on the glutamatergic system, the serotonergic system, specifically 5-HT2A receptor signaling, has received limited attention. Psilocin, the active metabolite of psilocybin and a known 5-HT2A...

DOI: 10.1152/jn.00519.2025 Full text Psilocin Auditory steady-state response Gamma oscillations Neural synchrony +1

N-methyl d-aspartate receptor hypofunction reduces steady state visual evoked potentials.

Journal of Neurophysiology July 14, 2025 Alexander Schielke, Bart Krekelberg

The dynamic coordination of neural activity across populations of neurons is impaired in neuropsychiatric disorders. Here, we focused on the large-scale rhythmic responses induced by flickering light. These so-called steady-state visual evoked potentials (SSVEPs) are reduced in people with schizophrenia (Sz). A large body of work has identified hypofunction of the N-methyl d-aspartate receptor...

DOI: 10.1152/jn.00296.2024 Full text Nmda receptor hypofunction Schizophrenia research Psychiatric disorders Neuropsychiatric conditions +12

Rebound electroencephalographic responses to nitrous oxide exposure in men.

Journal of Neurophysiology May 1, 2025 Petra Valtonen, Stanislav Rozov, Iina Annala et al.

Nitrous oxide (N2O) may elicit antidepressant effects after its elimination from the brain. We sought to investigate whether short-term administration of N2O triggers power within the delta (0.5-4 Hz) and/or theta (4-7 Hz) frequency ranges in the electroencephalogram (EEG) after it's administration, as we have recently seen such rebound effects to N2O in studies conducted on mice. Twenty...

DOI: 10.1152/jn.00275.2024 Full text EEG N-methyl-d-aspartate nmda receptor Nitrous oxide Spectrogram

Volumetric mesoscopic electrophysiology: a new imaging modality for the nonhuman primate.

Journal of Neurophysiology April 1, 2025 Tobias Teichert, László Papp, Ferenc Vincze et al. 1 citation

The primate brain is a densely interconnected organ whose function is best understood by recording from the entire structure in parallel, rather than parts of it in sequence. However, available methods either have limited temporal resolution (functional magnetic resonance imaging; fMRI), limited spatial resolution (macroscopic electroencephalography), or a limited field of view (microscopic...

DOI: 10.1152/jn.00399.2024 Full text Ketamine EEG Local filed potentials Resting state +5

Psilocybin decreases neural responsiveness and increases functional connectivity while preserving pure-tone frequency selectivity in mouse auditory cortex

Journal of Neurophysiology May 29, 2024 Adam T. Brockett, Nikolas A. Francis 8 citations

Recent studies have shown promising therapeutic potential for psychedelics in treating neuropsychiatric conditions. Musical experience during psilocybin-assisted therapy is predictive of treatment outcome, yet little is known about how psilocybin affects auditory processing. Here, we conducted two-photon imaging experiments in auditory cortex of awake mice that received a dose of psilocybin....

DOI: 10.1152/jn.00124.2024 Full text Psilocybin Magic mushrooms Psychedelics hallucinogens Hearing +6

Inhalation boosts perceptual awareness and decision speed.

Journal of Neurophysiology September 1, 2023 Ludovic Molle, Alexandre Coste, Charles-Etienne Benoit et al.

The emergence of consciousness is one of biology's biggest mysteries. During the past two decades, a major effort has been made to identify the neural correlates of consciousness, but in comparison, little is known about the physiological mechanisms underlying first-person subjective experience. Attention is considered the gateway of information to consciousness. Recent work suggests that the...

DOI: 10.1152/jn.00492.2022 Full text Attention Consciousness Decision-making Respiration

Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness.

Journal of Neurophysiology October 1, 2022 Don M Tucker, Phan Luu, Mark I Johnson 16 citations

Neurophysiological mechanisms are increasingly understood to constitute the foundations of human conscious experience. These include the capacity for ongoing memory, achieved through a hierarchy of reentrant cross-laminar connections across limbic, heteromodal, unimodal, and primary cortices. The neurophysiological mechanisms of consciousness also include the capacity for volitional direction...

DOI: 10.1152/jn.00328.2022 Full text Phenomenology Collothalamic Consciousness Lemnothalamic +1

The respiratory modulation of interoception.

Journal of Neurophysiology April 1, 2022 Ludovic Molle, Alexandre Coste

In a recent article published in The Journal of Neurophysiology titled "Sensitivity to changes in rate of heartbeats as a measure of interoceptive ability," Larsson et al. (J Neurophysiol 126: 1799-1813, 2021) introduce a new method to evaluate the interoceptive ability and report a surprising tendency in humans to perceive fewer heartbeats during spontaneous increases in resting heart rate....

DOI: 10.1152/jn.00027.2022 Full text Consciousness Heartbeat Interoception Respiration

Opioids cause dissociated states of consciousness in C57BL/6J mice.

Journal of Neurophysiology October 1, 2021 Christopher B O'Brien, Clarence E Locklear, Zachary T Glovak et al. 18 citations

The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of consciousness. The present study tested the hypothesis that antinociceptive doses of fentanyl, morphine, or buprenorphine differentially alter the...

DOI: 10.1152/jn.00266.2021 Full text Buprenorphine Correlates of consciousness Fentanyl Morphine +1

Don't tell anyone: the importance of no-report paradigms in neuroscience of consciousness.

Journal of Neurophysiology March 31, 2021 M. del Vecchio

The neural correlates of perceptual awareness are usually investigated by comparing experimental conditions in which subjects are aware or not aware of the delivered stimulus. This, however implies that subjects report their experience, possibly biasing the neural responses with the post-perceptual processes involved. This Neuro Forum article reviews evidence from an electroencephalography...

DOI: 10.1152/jn.00569.2020

Temporal neural mechanisms underlying conscious access to different levels of facial stimulus contents.

Journal of Neurophysiology April 1, 2018 Shen-Mou Hsu, Yu-Fang Yang

An important issue facing the empirical study of consciousness concerns how the contents of incoming stimuli gain access to conscious processing. According to classic theories, facial stimuli are processed in a hierarchical manner. However, it remains unclear how the brain determines which level of stimulus content is consciously accessible when facing an incoming facial stimulus. Accordingly,...

DOI: 10.1152/jn.00747.2017 Full text Meg P300 Alpha phase Consciousness

BOLD temporal variability differentiates wakefulness from anesthesia-induced unconsciousness.

Journal of Neurophysiology March 1, 2018 Alexis T Baria, Maria V Centeno, Mariam E Ghantous et al.

Even though a number of findings, based on information content or information integration, are shown to define neural underpinnings characteristic of a conscious experience, the neurophysiological mechanism of consciousness is still poorly understood. Here, we investigated the brain activity and functional connectivity changes that occur in the isoflurane-anesthetized unconscious state in...

DOI: 10.1152/jn.00714.2017 Full text Awake Consciousness FMRI Graph theory +1

Leg muscle vibration modulates bodily self-consciousness: integration of proprioceptive, visual, and tactile signals.

Journal of Neurophysiology March 2, 2011

Leg muscle vibration modulates bodily self-consciousness: integration of proprioceptive, visual, and tactile signals.

DOI: 10.1152/jn.00744.2010

Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.

Journal of Neurophysiology September 2007 Maeng-Hee Kang-Park, Wilkie A Wilson, Cynthia M Kuhn et al.

The impairment of learning and memory is one of the most powerful and least understood effects of marijuana although the hippocampal formation appears to be one CNS region mediating these effects. We have shown that systemic injection of Delta9-tetrahydrocannabinol (THC), an active component of marijuana, impairs spatial learning more efficaciously in adolescent rats, compared with adult rats,...

DOI: 10.1152/jn.00091.2007 Full text

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