Journal of Neurophysiology
April 1, 2026
Yoshihiro Iwamura, Kantaro Nishigori, Masataka Yamaguchi et al.
(R,S)-Ketamine, a dissociative anesthetic, has shown rapid and sustained antidepressant effects at lower doses than those required for anesthetic effects in patients with treatment-resistant depression. However, its use is limited because it causes side effects, including psychotomimetic symptoms and dependence. The enantiomer (R)-ketamine was reported to promote antidepressant-like effects in...
Journal of Neurophysiology
April 1, 2026
Yuri I Arshavsky
In recent years, numerous publications have emerged claiming that animals possess consciousness. Moreover, neurophysiological literature has discussed the possible existence of consciousness in artificial intelligence (AI). Both ideas stem from analyses of the behavior of animals and AI systems. Here, I argue that it is impossible to draw conclusions about animal consciousness based solely on...
Journal of Neurophysiology
April 1, 2026
Inga Griškova-bulanova, Čestmír Vejmola, Tomáš Páleníček
Auditory steady-state responses (ASSRs), particularly at 40 Hz, are promising biomarkers for psychiatric disorders involving dysregulated neural synchronization. Although most ASSR studies have focused on the glutamatergic system, the serotonergic system, specifically 5-HT2A receptor signaling, has received limited attention. Psilocin, the active metabolite of psilocybin and a known 5-HT2A...
Journal of Neurophysiology
July 14, 2025
Alexander Schielke, Bart Krekelberg
The dynamic coordination of neural activity across populations of neurons is impaired in neuropsychiatric disorders. Here, we focused on the large-scale rhythmic responses induced by flickering light. These so-called steady-state visual evoked potentials (SSVEPs) are reduced in people with schizophrenia (Sz). A large body of work has identified hypofunction of the N-methyl d-aspartate receptor...
Journal of Neurophysiology
May 1, 2025
Petra Valtonen, Stanislav Rozov, Iina Annala et al.
Nitrous oxide (N2O) may elicit antidepressant effects after its elimination from the brain. We sought to investigate whether short-term administration of N2O triggers power within the delta (0.5-4 Hz) and/or theta (4-7 Hz) frequency ranges in the electroencephalogram (EEG) after it's administration, as we have recently seen such rebound effects to N2O in studies conducted on mice. Twenty...
Journal of Neurophysiology
April 1, 2025
Tobias Teichert, László Papp, Ferenc Vincze et al.
1 citation
The primate brain is a densely interconnected organ whose function is best understood by recording from the entire structure in parallel, rather than parts of it in sequence. However, available methods either have limited temporal resolution (functional magnetic resonance imaging; fMRI), limited spatial resolution (macroscopic electroencephalography), or a limited field of view (microscopic...
Journal of Neurophysiology
May 29, 2024
Adam T. Brockett, Nikolas A. Francis
8 citations
Recent studies have shown promising therapeutic potential for psychedelics in treating neuropsychiatric conditions. Musical experience during psilocybin-assisted therapy is predictive of treatment outcome, yet little is known about how psilocybin affects auditory processing. Here, we conducted two-photon imaging experiments in auditory cortex of awake mice that received a dose of psilocybin....
Journal of Neurophysiology
September 1, 2023
Ludovic Molle, Alexandre Coste, Charles-Etienne Benoit et al.
The emergence of consciousness is one of biology's biggest mysteries. During the past two decades, a major effort has been made to identify the neural correlates of consciousness, but in comparison, little is known about the physiological mechanisms underlying first-person subjective experience. Attention is considered the gateway of information to consciousness. Recent work suggests that the...
Journal of Neurophysiology
October 1, 2022
Don M Tucker, Phan Luu, Mark I Johnson
16 citations
Neurophysiological mechanisms are increasingly understood to constitute the foundations of human conscious experience. These include the capacity for ongoing memory, achieved through a hierarchy of reentrant cross-laminar connections across limbic, heteromodal, unimodal, and primary cortices. The neurophysiological mechanisms of consciousness also include the capacity for volitional direction...
Journal of Neurophysiology
October 1, 2021
Christopher B O'Brien, Clarence E Locklear, Zachary T Glovak et al.
18 citations
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of consciousness. The present study tested the hypothesis that antinociceptive doses of fentanyl, morphine, or buprenorphine differentially alter the...
Journal of Neurophysiology
April 1, 2018
Shen-Mou Hsu, Yu-Fang Yang
An important issue facing the empirical study of consciousness concerns how the contents of incoming stimuli gain access to conscious processing. According to classic theories, facial stimuli are processed in a hierarchical manner. However, it remains unclear how the brain determines which level of stimulus content is consciously accessible when facing an incoming facial stimulus. Accordingly,...