Despite the existence of current treatments for major depressive disorder (MDD), depression symptoms and burdens often persist, prompting the need for novel therapies, including psychedelic-assisted therapy (PAT), with promising potential for early and durable antidepressant responses. Objectives: This research aims to compare pharmacist opinions regarding logistical and ethical considerations...
Psilocybin simultaneously holds six contradictory legal classifications across jurisdictions: Schedule I (US federal), Breakthrough Therapy (FDA), legal therapeutic use (Oregon, Colorado), Schedule 8 medical use (Australia), and pending rescheduling review (DEA/HHS). This regulatory fragmentation constitutes a classification cascade—a multi-stage disruption propagated through administrative,...
Abstract Meditation can act as a protection for mental well-being in late years, by helping older adults to challenge the pervasive effects of chronic illness. The primary objectives of this qualitative research study are to: (a) to examine older adults’ experiences of meditation while living with chronic disease, and (b) to analyze how meditation is perceived to influence their mental health....
Psychedelics a class of psychoactive compounds such as psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) are undergoing a scientific renaissance. Studies since 2020 have shown their therapeutic promise in mental health treatment. This Commentary synthesizes historical usage, current neuroscientific and clinical evidence, and explores ethical and regulatory frontiers for...
Autism Spectrum Disorder (ASD) is a lifelong condition marked by challenges in social communication and repetitive behaviors. Current treatments, primarily behavioral therapies, often fail to address the core symptoms. Recent research has explored the potential of psychedelics, such as LSD, psilocybin, and MDMA, as a new therapeutic approach. While these substances primarily modulate the...
Mushroom use dates back to ancient times, and it currently remains significant among indigenous and urban populations as a medicinal option. Psilocybe species are suggested to modify emotions when administered in macro- or microdose form for the treatment of anxiety and depression, both often affected by a delayed onset and adverse effects of current pharmacological therapy. The objective of...
BackgroundCognitive behavioral therapy (CBT) is the most effective treatment for binge eating disorder (BED) but is limited by modest efficacy and low reach of in-person delivery. Combining mindfulness training with CBT could enhance efficacy by targeting emotion dysregulation, a key factor in BED that CBT does not adequately target. Digital delivery can enhance the reach of treatment....
Esta revisión analiza cómo la suplementación con L-triptófano en el sustrato de cultivo de Psilocybe cubensis potencia la biosíntesis de psilocibina vía las enzimas PsiD, PsiH, PsiK y PsiM, alcanzando aumentos significativos en laconcentración alcaloide respecto a controles sin suplemento.La psilocibina después de ser ingerida se convierte en psilocina por un proceso de desfosforilación, que...
The chapter presents a unified examination of yoga and its body-mind approach by exploring neural mechanisms, psychological and philosophical aspects. It examines how yoga facilitates the body-mind connection through yogic texts and scientific study, such as breath regulation (pranayama), postural awareness (asana) and meditative focus (dhyana). This study applies polyvagal theory,...
The defining feature of emotion regulation is the activation of a goal to influence the trajectory of emotion.Emotion regulation strategies often involve efforts to either decrease negative emotions or increase positive ones and are associated with a range of possible outcomes.Depressive rumination is an emotion regulation strategy involving repetitive negative thinking about oneself, feelings,...