Clinical trials and naturalistic studies describe psychedelics under markedly different exposure conditions. This narrative review searched PubMed/MEDLINE, the Cochrane Library, ClinicalTrials.gov, and regulatory sources through 15 July 2026, and examined safety and outcomes across four dimensions of exposure: dose, frequency, person, and context. In screened adults receiving one to three...
In Basel, only a few hundred meters from where LSD was first synthesized, we tested LSD-assisted therapy for major depression in a randomized trial comparing two high doses with two low doses, each paired with supportive psychotherapy. This Backstory reflects on treating patients, long dosing days, and what remains uncertain.
Implementation variability is hypothesized to be a key treatment effect modifier of universal, school-based mental health interventions, but the evidence base remains meagre. We used Complier Average Causal Effect (CACE) estimation to determine if dosage variability modified treatment effects of relaxation techniques and mindfulness-based exercises in the INSPIRE cluster randomised trial....
Abstract Post-traumatic stress disorder (PTSD) is a highly prevalent, debilitating psychiatric condition. Existing treatments are ineffective for many patients. 3,4- methylenedioxymethamphetamine (MDMA)-assisted psychotherapy has demonstrated substantial clinical efficacy but relies on prolonged, resource-intensive therapeutic protocols that limit scalability and accessibility. Here, we...
Background/Objectives: Psilocybin-assisted therapy has progressed from early proof-of-concept work to a substantially expanded evidence base, with four pivotal studies published in 2025–2026 that were not incorporated into earlier reviews. This review synthesizes the pharmacological and neurobiological foundations of psilocybin and appraises clinical evidence across major depressive disorder...
Post-traumatic stress disorder places patients at risk for emergence agitation following surgical procedures under general anaesthesia. Gynaecological procedures, sphincteroplasty, and surgical interventions involving the pelvic floor can involve vulnerable patient positioning in theatre, with inserted catheters and sensory stimulation. Such interventions could contribute to postoperative...
본 연구는 MBCT, 예술치료, 치유농업 등을 통합적으로 적용한 집단프로그램이 중년여성의 우울증상 완화에 미치는 긍정적 가능성 및 영향관계를 탐색해 보는 데 목적이 있다. 이에 MBCT의 비판단적 인식과 수용적 태도를 기반으로 하여 미술, 시, 글쓰기 등 예술적 표현 활동과 치유농업 활동을 적용한 통합치유 집단프로그램을 구성하였다. 연구대상은 K지역에 거주하는 중년여성 11명을 대상으로 하였으며, 8주간 주 1회, 회기당 120분씩 프로그램을 실시하였다. 프로그램의 긍정적 가능성을 탐색하기 위해 한국우울척도(KDS), 상태-특성불안검사(K-STAI), 자기효능감 척도를 활용하여 사전·사후 검사를 실시하고 대응표본 t-검증을 수행하였다. 연구 결과, 프로그램 참여 이후 우울과 불안 수준이 유의하게...
BACKGROUNDPerimenopausal women are vulnerable to both sleep disturbances and depressive symptoms.Mindfulness has been associated with better psychological well-being and sleep outcomes, but the specific psychological pathway linking mindfulness to sleep quality in this population remains insufficiently defined.In particular, it remains unclear whether depressive symptoms represent an...
Sleep disturbances are common in older adults with MCI, associated with cognitive decline and reduced quality of life. Pharmacological treatment remains common despite safety concerns. Meditation-based interventions may improve sleep and psychological well-being, yet evidence among individuals with MCI remains limited. This systematic review evaluated the effects of MBIs on sleep quality among...
Stress may exacerbate neuroinflammation and symptom burden in people with multiple sclerosis (pwMS). Engaging in stress-reducing activities (SRAs), such as meditation and mind-body practices, may reduce inflammation thereby improve health outcomes. The objective of the study was to assess determinants of SRAs use and prospective associations with health outcomes. Data from 952 pwMS were...