Revista de Estudos Interdisciplinares
August 6, 2026
Helena Victor Leite Panadés, Isadora Queiroz Graça, Maria Fernanda Vasconcelos Mascarenhas Clementino et al.
Introduction: Treatment-resistant depression (TRD) is characterized by the persistence of depressive symptoms following at least two adequate therapeutic trials with distinct classes of antidepressants. Given the limited efficacy of the traditional monoaminergic model and the high socioeconomic and functional burden of the disease, interventions with rapid mechanisms of action have become...
Journal of Parkinson's disease
August 6, 2026
Akila Rayapuraju, Preeti U. Reed, Jennifer Liu et al.
BackgroundAnxiety and other non-motor symptoms can greatly diminish quality of life in people with Parkinson's Disease (PD). Yet, few randomized controlled trials (RCTs) have assessed accessible, non-pharmacological mental health treatments for people with PD.ObjectiveTo assess the feasibility and impact of brief, remotely-delivered meditation and breathwork on neuropsychiatric symptoms in...
Artefactum
August 6, 2026
Laura Alves Dutra, Anne Karolyne Alves Martins, Marina Camarão Oliveira et al.
Introduction:Treatment-resistant depression (TRD) is defined by the persistence of depressive symptoms despite at least two adequate trials with different classes of antidepressants. Limitations of traditional monoaminergic drugs have driven the search for rapid-acting, innovative interventions such as ketamine and electroconvulsive therapy (ECT), which target neuroplasticity and the...
Frontiers in Public Health
August 6, 2026
R. Cameron Wolf, Rick Lambert, Sara Shoar et al.
Use of psychedelic substances is increasing across unregulated, state-regulated, research, ceremonial/religious, and medical settings in the United States. Concurrently, a growing body of clinical research signals the potential for therapeutic applications for specific psychedelics in the treatment of depression, post-traumatic stress disorder, substance use disorders, and other health...
Frontiers in Psychiatry
August 6, 2026
Maria Laura Mele, Stefano Federici
IntroductionPsychedelic-assisted therapy (PAT) is an emerging complex intervention for psychiatric and existential conditions (i.e., forms of distress related to meaning, mortality, and identity, such as that arising in life-threatening illness); however, a systematic characterization of the evaluation methods used across the entire clinical intervention remains incomplete. This scoping review...
Frontiers in Psychiatry
August 5, 2026
Dominika Fortuna, Krystyna Golonka
Background Depersonalization can be conceptualized as an emotion regulation mechanism that may emerge in response to prolonged stress and overstimulation. Individuals differ in their tendency to rely on this mechanism, with varying levels of depersonalization experiences observed in the general population. The present study aimed to develop and validate a brief version of Depersonalization...
Journal of Medical Ethics
August 5, 2026
JingYi Zhang, Dominic Sisti
Intravenous ketamine and intranasal esketamine have shown rapid effects in reversing suicidality and improving depressive symptoms. In countries that allow psychiatric euthanasia and/or assisted suicide (EAS), we argue that potentially effective treatments for suicidal ideation and behaviour, such as ketamine, should be required before allowing patients to access psychiatric EAS. Ketamine can...
JAMA Psychiatry
August 5, 2026
Michael Elliott, Olga Chernoloz
To the Editor In JAMA Psychiatry, Cubała et al. report that inhaled mebufotenin (GH001) reduced depression severity by 15.5 points more than placebo on the Montgomery-Åsberg Depression Rating Scale (MADRS) at 1 week, with 57.5% of patients achieving remission vs 0% in the placebo group. The effect size (d = −2.0) overwhelmingly surpasses those of selective serotonin reuptake inhibitors,...
Research Square
August 4, 2026
Francisco Domínguez
preprint
Abstract We introduce BMIM II (Biophysical Multiscale Integration Model), a dynamical framework proposing that cognitive transduction emerges from the dynamics of coupled Stuart-Landau oscillators subject to multiplicative neural gains and thermodynamic noise. The model unifies endogenous, exogenous, and executive gain channels into a single multiplicative manifold whose product determines the...
Molecular Psychiatry
August 4, 2026
Kim P. C. Kuypers, Natasha L. Mason, Aurelie Carlier et al.
Women experience a disproportionate burden of affective and stress-related disorders, with symptom variability shaped by endocrine transitions across the menstrual cycle, pregnancy, postpartum, and menopause. Although psychedelic-assisted therapies are increasingly investigated for these conditions, hormonal state represents a largely unaccounted determinant of variability in exposure,...