BJPsych Open
June 1, 2025
Anna Borissova, Allan H. Young, Mitul A. Mehta et al.
Aims: Ketamine and behavioural activation (BA) reduce levels of anhedonia in major depressive disorder (MDD), though neither resolves anhedonia. Combining these treatments could yield additive or even multiplicative benefits. This poster summarises the development of a PhD fellowship proposal, discussing: (1) the initial patient and public involvement (PPI) interviews, exploring views on...
CHEST critical care
June 1, 2025
Lucas C Wollenman, Austin M Tipold, Matthew W. Semler et al.
1 citation
One of 3 patients in the ICU receiving mechanical ventilation demonstrates posttraumatic stress disorder (PTSD). A single dose of ketamine has been shown to reduce PTSD symptoms in outpatients with chronic PTSD, but its long-term effect is unknown in patients who are critically ill and mechanically ventilated. Is ketamine, when used for induction of anesthesia before emergency tracheal...
Neuroscience & Biobehavioral Reviews
June 1, 2025
Georg Northoff, Bianca Ventura
21 citations
Neuroscience faces the challenge of connecting brain and mind, with the mind manifesting in first-person experience while the brain's neural activity can only be investigated in third-person perspective. To connect neural and mental states, Neurophenomenology provides a methodological toolkit for systematically linking first-person subjective experience with third-person objective observations...
Cureus
June 1, 2025
Amy Avakian, Zachary I Merhavy
1 citation
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuroinflammation. Despite extensive research, current therapeutic options offer limited symptomatic relief without altering disease progression. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist traditionally used as an anesthetic, has garnered...
Behavioural Pharmacology
June 1, 2025
Ronan Depoortère, Mariusz Papp, Piotr Gruca et al.
2 citations
Ketamine displays efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model. It rapidly reverses anhedonia (CMS-induced sucrose consumption deficit) and attenuates working memory deficit (novel object recognition: NOR) following both systemic (intraperitoneal, i.p.) administration or local administration in the prefrontal cortex (PFC). However, the...
Journal of Occupational and Environmental Medicine
June 1, 2025
Vivian Wl Tsang, Michelle Cq Lin, Cassandra M Choles et al.
4 citations
Firefighters display elevated risk for diagnoses of mental health illnesses. Psychedelic-assisted therapies show promise in the treatment of clinically challenging conditions. This observational case series analyzed data from firefighters with mental health diagnoses who participated in a 12-week ketamine-assisted group therapy treatment plan. Questionnaire scores (Generalized Anxiety Disorder...
Psychiatry Research
June 1, 2025
Flávia Vieira, Ana Teresa Caliman-Fontes, Breno Souza-Marques et al.
Assessment measures for suicidal behavior range from depression scales to longer suicide-specific instruments. In this review, we systematically summarize and discuss the currently used instruments for assessing suicidal behavior in the context of ketamine and its enantiomers. We searched Medline/PubMed, Embase, and PsycINFO databases for ketamine (and its enantiomers) human studies exploring...
Expert Opinion on Emerging Drugs
June 1, 2025
Maria-Alejandra Umbacia, Marta Ximena Leon, Jose-Manuel Quintero et al.
Although long known for their psychoactive effects, psychedelic drugs have only recently been investigated for medicinal use. Psilocybin has attracted the greatest interest with studies suggesting that it may be a useful agent in psychiatry and in palliative care. Clinical trials that included psilocybin were searched in PubMed, Embase, and ClinicalTrials.gov, demonstrating that adult...
Clinical Gerontologist
May 31, 2025
Demetra Christodoulou, Suzanne Reeves, Naashoma P Carvalho et al.
2 citations
This systematic review assessed use of third-wave psychotherapies in reducing psychological distress and improving psychological well-being and quality of life in people with Parkinson's disease and critically evaluated intervention adaptations. A literature search, conducted across five databases identified randomized controlled trials (RCTs) evaluating third-wave psychotherapies for...
Medicine
May 30, 2025
Zuoju Zhang, Yanhong Dong, Yuxin Sun
2 citations
The prevention and management of cerebrovascular diseases, particularly cerebral infarction - the most prevalent type of cerebrovascular disease - pose significant challenges, severely affecting patients' physical and mental health. Mindfulness-based cognitive therapy (MBCT) has been shown to be effective in treating various mental and chronic conditions. However, there is limited evidence on...