Brain Sciences
May 16, 2025
Edmund T Rolls
7 citations
A unified theory of emotion and motivation is updated in which motivational states are states in which instrumental goal-directed actions are performed to obtain anticipated rewards or avoid punishers, and emotional states are states that are elicited when the (conditioned or unconditioned) instrumental reward or punisher is or is not received. This advances our understanding of emotion and...
Pediatric Reports
May 14, 2025
Bruno Daniel Carneiro, Daniel Humberto Pozza, José Tiago Costa-Pereira et al.
6 citations
Mindfulness-Based Interventions (MBIs) are important tools to address mental health issues in children and adolescents. However, previous studies provided variable results that suggest that the effectiveness of those third-wave Cognitive Behavioral Therapies remains uncertain. The main objective is to assess the impact of MBIs on anxiety, depression, and stress in children and adolescents. The...
Trials
May 13, 2025
Ka Yan, Nessa Ikani, Cleoputri Yusainy et al.
1 citation
Elevated levels of stress, anxiety, and depression persist among undergraduate students in Eastern countries, including Indonesia. Access to mental healthcare resources, however, remains difficult and costly for most young people. Furthermore, there is a strong tendency to avoid seeking professional help. The primary aim of this study is to investigate the effects of a brief 14-day online...
Scientific Reports
May 12, 2025
Naser M Alotaibi, Latifah Alenezi, Feddah M Ahmad et al.
1 citation
The purpose of this research was to study the effectiveness of a stress management program among students at the Health Science Center (HSC), Kuwait University. This study utilized a quasiexperimental research design in which the participants were randomly assigned to one of two groups: (1) the control group or (2) the experimental (intervention) group. The participants received a comprehensive...
Science
May 8, 2025
Z Zack Ma, Natalie J Guzikowski, Ji-Woon Kim et al.
44 citations
Repeated ketamine treatment to maintain a rapid antidepressant effect can lead to side effects over time, highlighting an unmet clinical need for sustaining this drug's antidepressant action from a single administration. Ketamine-induced synaptic potentiation at CA3-CA1 synapses has been proposed to be a key synaptic substrate for antidepressant action. Here, we found that ketamine-induced...
Science
May 8, 2025
Kenji Hashimoto
9 citations
Boosting an intracellular signaling pathway preserves the antidepressant response to ketamine.
International Journal of Yoga
May 5, 2025
Rahul Geeta Arya, Deepsikha Srivastava, B. R. Divya et al.
This systematic review aimed to evaluate the impact of yoga interventions on preventing and alleviating mental health issues, including stress, anxiety, burnout, depression, and other related factors among nursing professionals and students. The review adhered to the PRISMA guidelines and was registered in PROSPERO (CRD42024512366). A comprehensive literature search was conducted in Google...
Biological Psychiatry
May 5, 2025
Matthew B Pomrenze, Sam Vaillancourt, Pierre Llorach et al.
11 citations
Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. This mechanism may differentiate ketamine from other NMDA receptor antagonists. Animal models that reflect OR-dependent behavioral effects of ketamine may shed light on the...
Experimental Brain Research
May 4, 2025
Ceyda Özler, Esra Özkan, Narges Shomalizadeh et al.
1 citation
Recent studies in mouse models have demonstrated that ketamine and rapastinel induce rapid-acting and sustained antidepressant effects in major depressive disorder (MDD). However, it remains unclear how ketamine's and rapastinel's opposing mechanisms of action-NMDAR antagonist and NMDAR positive allosteric modulator, respectively-result in similar antidepressant-like effects. Furthermore,...
Acta Médica Portuguesa
May 2, 2025
Pedro Mota, Jorge Encantado, Laura C. Carvalho et al.
1 citation
Ketamine has garnered attention for its rapid efficacy in alleviating depressive symptoms in treatment-resistant depression, offering a novel mechanism as a non-monoaminergic agent. Despite its potential, limited research has explored mental health professionals' perspectives on its use. This study assesses the attitudes, knowledge, and concerns of Portuguese psychiatrists and psychologists...