Depression: all studies (page 348) - The Consciousness Library

The boon and bane of nitrous oxide.

European Archives of Psychiatry and Clinical Neuroscience September 1, 2025 Golo Kronenberg, Georgios Schoretsanitis, Erich Seifritz et al.

Nitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be...

DOI: 10.1007/s00406-024-01801-3 Full text Depression Abuse Homocysteine Methylmalonic acid +2

Intravenous Ketamine Followed by Intranasal Esketamine in 2 Subsequent Treatment-resistant Depressive Episodes: Insights From a Case Series.

Journal of Psychiatric Practice September 1, 2025 Matteo Carminati, Mattia Tondello, Barbara Barbini et al. 2 citations

Treatment-resistant depression (TRD) remains a relevant issue in psychiatric practice, driving the exploration of innovative therapeutic alternatives. Ketamine and its enantiomer, esketamine, are emerging as treatments known for their effectiveness as rapid-acting antidepressants. Although previous comparative studies have highlighted some differences in their effects, they did not concurrently...

DOI: 10.1097/pra.0000000000000879 Full text Esketamine Treatment-resistant depression Antidepressant treatment Case series

Ketamine Therapy in Psychiatry: A Comprehensive Review

Journal of Psychiatric Nursing August 30, 2025 Asif Khan, Satyaveer *, Shrikant K. Nair et al.

Ketamine, traditionally known as an anesthetic agent, has garnered attention for its rapid acting antidepressant properties, particularly in patients with treatment resistant depression (TRD). The compound’s unique pharmacological profile primarily as an NMDA receptor antagonist has enabled its repositioning in psychiatric settings, where conventional antidepressants often fall short. This...

DOI: 10.21088/jpn.2277.9035.14225.4 Full text Ketamine Treatment-resistant depression Antidepressant Depression economics +7

General anesthesia dissociates discrete components of ketamine neurophysiology

medRxiv August 7, 2025 Ben Deverett, Duan Li, Theresa R. Lii et al. preprint

Structured Abstract Importance Ketamine has well known dissociative, analgesic, and antidepressant properties, but it is unknown whether the neurophysiologic effects that are associated with these properties can be modulated separately from one another. Given prior studies that link specific cortical oscillations with specific therapeutic effects, it is likely that modulating selective aspects...

DOI: 10.1101/2025.08.05.25333019 Full text Ketamine Treatment-resistant depression Major depressive disorder Dissociative +7

Efficacy of an online mindfulness program (MindOnLine) to reduce fear of recurrence in people living with-and beyond-breast, prostate or colorectal cancer: a randomized controlled trial.

EClinicalMedicine August 1, 2025 Patricia M Livingston, Natalie Winter, Lahiru Russell et al.

Fear of cancer recurrence (FCR) is a prevalent and debilitating condition that effects around 60% of people living with cancer. It is severe, persistent, and imposes a significant financial burden on the healthcare system. Given FCR's profound impact on mental health and quality of life, adopting targeted interventions to mitigate its effects is essential. This study reports on the efficacy of...

DOI: 10.1016/j.eclinm.2025.103373 Full text Anxiety Depression Mindfulness Cancer +2

Easing the burden: a pilot study on the impact of mindfulness on the mental health of Brazilian medical students.

BMC Medical Education August 1, 2025 Vinicius Vieira Neves, Daniel Teixeira Dos Santos, Marcelo Demarzo et al.

BACKGROUND: Mental health disorders, such as anxiety and depression, are more prevalent in medical students than in the general population. Mindfulness-based interventions (MBIs) have shown evidence of effectiveness in treating these conditions. However, findings among medical students are mixed, particularly in Brazilian samples. This study aims to evaluate the feasibility and preliminary...

DOI: 10.1186/s12909-025-07726-2 Full text Depression Anxiety Humans Feasibility studies +13

The association between dream activity and alexithymia during pregnancy: A cross-sectional study in a sample of pregnant women.

Journal of Sleep Research August 1, 2025 Marta Spinoni, Serena Scarpelli, Ilaria Di Pasquale Benedetti et al. 2 citations

The gestational period is a sensitive time marked by significant changes that can affect women's sleep and dreaming processes, with an augmented frequency and recall of dreams suggesting that dreaming represents an adaptive mechanism of emotional regulation. This study investigates the relationship between pregnancy-related variables, alexithymia, and depressive symptoms in influencing dream...

DOI: 10.1111/jsr.14423 Full text Depression Dreaming Alexithymia Pregnancy

Is ketamine safe for individuals in higher level of care treatment for eating disorders? Analysis of safety of subanesthetic ketamine in 104 patients.

Journal of Psychiatric Research August 1, 2025 Elizabeth Wassenaar, Dan V. Blalock, Alan Duffy et al. 4 citations

Eating disorders are among the most challenging and fatal mental illnesses and, due to the complication of medical instability caused by malnutrition or other disordered eating behaviors, pose unique treatment challenges for patients with co-occurring depression and mood disorders. Randomized control trials have demonstrated "rapid and robust antidepressant effects" of generic ketamine in...

DOI: 10.1016/j.jpsychires.2025.05.055 Full text Mental health research Antidepressive agents Malnutrition Mood disorders +4

Construction and multidimensional effect evaluation of a mindfulness-based second victim intervention support programme for intensive care unit nurses: a case-control study.

BMC Nursing July 29, 2025 Xiaolei Chen, Aiyan Du, Mei Yu et al.

Intensive care units (ICUs) are high-risk, high-stress environments that substantially increase the likelihood of nursing staff becoming second victims (SVs). However, current research on mindfulness interventions for ICU nurses facing SV effects is limited, particularly due to the lack of systematic intervention protocols tailored to the specific work scenarios of ICU staff. This study aims to...

DOI: 10.1186/s12912-025-03478-y Full text Anxiety Depression Mindfulness Psychological distress +1

Beyond Anesthesia: Ketamine’s Expanding Role in Chronic Pain and Psychiatric Disorders

Journal of Integrative Neuroscience July 25, 2025 Christopher Zaki 1 citation

OBJECTIVE: This review explores ketamine's expanding role in managing both chronic pain and mental health conditions, focusing on its pharmacologic mechanisms, clinical applications, and therapeutic potential. We assess its analgesic properties, FDA-approved application in the form of Spravato (esketamine) for depression, and off-label use for analgesia and psychiatric disorders. METHODS: A...

DOI: 10.31083/jin26766 Ketamine Major depressive disorder Anxiety Chronic pain +10