Anton Skolzkov
Social studies show an increasing number of people with anxiety disorders and depression around the world. Selected data on Russia confirm this trend. Despite the overall improvement in the world economic situation in recent decades, the stress level has not decreased. Freshmen are particularly vulnerable to stress. This pilot study assesses the mindfulness training effectiveness, which was...
Anton Skolzkov
Globally, there has been an increase in the number of people with anxiety disorders and depression which is confirmed by particular Russian data. Despite overall improvements in the global economic situation in recent decades, general stress levels have not decreased. University freshmen are particularly vulnerable to stress. Therefore, this pilot study assesses the effectiveness of mindfulness...
Nestor Girala
Introduction There is a growing and renewed interest in the use of hallucinogenic drugs in the treatment of psychiatric disorders, especially since the FDA approval of esketamine treatment for resistant depression. The response to hallucinogenic psychedelic substances (ayahuasca, psilocybin, LSD, ketamine) in the treatment of depression and addictions calls for a theoretical explanatory model....
Khush Jain, Fariah Rizwani, Nisarg Sawant et al.
preprint
Abstract Depression is a debilitating psychiatric disorder affecting millions worldwide. The Chronic Unpredictable Mild Stress (CUMS) model is widely used to simulate depression-related behavioural and neurobiological changes in rodents. This study evaluated the antidepressant-like effects of harmaline, a monoamine oxidase (MAO) inhibitor derived from Peganum harmala , in comparison to...
Amanda Timek, Catherine Daniels-Brady, Stephen Ferrando
preprint
Abstract Background : Anorexia nervosa is a life-threatening psychiatric illness with a high mortality rate and limited treatment options. This illness is frequently comorbid with major depressive disorder, leading to additional obstaces in patient quality of life, and increasing the mortality rate further due to risk of suicide. Ketamine, an competitive N-methyl-D-aspartate receptor...
Çağrı Özkurt
preprint
A recent living systematic review in Nature Mental Health found psilocybin reduced depression symptoms across 12 randomized controlled trials, with pooled effect g = 0.90. The original analysis assessed publication bias using Egger’s test, non-significant — but this test has limited power with few studies and cannot produce a bias-corrected estimate. We re-analysed the same open dataset using...
Research Square
Jack Swain, Davis Carter, Leonardo Vando et al.
preprint
Abstract Background Sleep disturbances are a significant public health burden affecting 50 to 70 million adults in the United States and contributing to impaired cognition, accelerated disease progression, and increased mortality risk. 1,2 Available pharmacological treatments carry notable safety and tolerability risks, while access to the leading evidence-based behavioral intervention,...
medRxiv
Warwick M. Green, Sanket B Raut, F.l.j. James et al.
4 citations
preprint
Abstract Post-Traumatic Stress Disorder (PTSD) causes broad impairments affecting quality of life. However, despite current treatment many people with PTSD do not fully recover. MDMA assisted psychotherapy has emerged as a new therapy for PTSD and its comorbidities. We aimed to analyse the current evidence for MDMA assisted psychotherapy in PTSD and associated quality of life, and physiological...
Research Square
Norihiro Okada, Kenshiro Oshima, Akiko Maruko et al.
preprint
Abstract In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and...
Research Square
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
preprint
Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with Major...