Journal of Medical Internet Research
September 2, 2026
Kathrin Hassdenteufel, Mitho Müller, Jan Multmeier et al.
Background: Pregnant women with ICD-10 (International Statistical Classification of Diseases, Tenth Revision) affective or stress-related disorders face an elevated risk of perinatal depression and anxiety, yet evidence on digital nonpharmacologic interventions for this population remains limited. Objective: This study evaluated the effectiveness of an 8-week digital mindfulness-based...
Psycho-Oncology
September 1, 2026
Shu Jing, Zhenwei Dai, Xuelin Yang et al.
Background: Patients with cervical cancer or High-Grade Squamous Intraepithelial Lesion (HSIL) often experience mental problems such as anxiety and depression. Online mindfulness-based interventions offer accessible mental health support. However, evidence for cervical cancer or HSIL patients remains scarce, and evaluations often rely solely on self-reported scales, with a lack of...
Women & health
August 25, 2026
Adebimpe Obembe, Jasmine Ramos, Emily Reis et al.
Premenstrual syndrome (PMS) affects many women of reproductive age, often disrupting daily activities. Mindfulness- and relaxation-based techniques, such as yoga and progressive muscle relaxation techniques, can alleviate both physical and psychosocial symptoms associated with PMS. This systematic review synthesized existing evidence on the effects of mindfulness and relaxation interventions on...
JMIR mHealth and uHealth
August 21, 2026
Houlin Hong, Matthew R Lootens, Rebecca Bachman et al.
Background: Young adults experience disproportionately high levels of stress, creating significant health challenges. This demographic often underuses traditional stress management methods due to perceived ineffectiveness, inconvenience, or stigma. Given these challenges, mobile virtual reality (VR) offers a novel, engaging, and accessible alternative stress management tool that may be more...
Frontiers in Nutrition
August 21, 2026
Agnieszka Mechlińska, Mariusz S. Wiglusz, Jakub Słupski et al.
This study evaluated the acute and short-term effects of repeated ketamine treatment on appetite in adult inpatients with treatment-resistant mood disorders, including major depressive disorder and bipolar disorder. Appetite, hunger, and desire to eat were assessed using the Visual Analog Scales (VAS) and the Simplified Nutritional Appetite Questionnaire (SNAQ) at baseline and at multiple time...
Der Nervenarzt
August 17, 2026
Stefan Vestring, Katharina Domschke, Claus Normann
Ketamine has been established as an anesthetic agent for decades. Around the turn of the millennium initial clinical studies demonstrated that subanesthetic doses of ketamine can exert antidepressant effects in treatment-resistant depression. These findings established the concept of an effective glutamatergic antidepressant treatment and initiated a paradigm shift. For many years, intravenous...
Psycho-Oncology
August 1, 2026
Hui Kou, Qiye Li, Xiaomei Hu et al.
Objectives: To examine whether a brief mindfulness training program was associated with changes in depressive symptoms among female patients with cancer, to explore potential psychological processes related to symptom change, and to examine differences in pre-to post-training changes according to baseline psychological risk profiles. Methods: This exploratory non-randomized controlled study...
Alpha psychiatry
August 2026
George Anderson
Understanding the physiological changes induced by ketamine in mood disorders, while reducing its side effects, is likely to contribute to a more comprehensive understanding of the physiology underlying mood disorders, as well as to the development of faster-acting and more efficacious antidepressant treatments. An extensive review of the literature on ketamine and the pathophysiology of...
Journal of Affective Disorders
August 1, 2026
João Paulo Atidio, Rodrigo Simonini Delfino, Igor Saque Garios et al.
Ketamine and esketamine have been increasingly used as adjunctive treatments for treatment-resistant depression (TRD), yet evidence on pharmacological interactions with commonly prescribed psychotropic medications remains limited. This study evaluated the association between concomitant lamotrigine, lithium, and benzodiazepine use and antidepressant outcomes during subcutaneous esketamine...
Pharmacology, Biochemistry, and Behavior
July 26, 2026
Peng Zhang, Mengyu Wu, Keke Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...